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Anti-CLD1/ CLDN1/ ILVASC monoclonal antibody
Anti-CLD1/ CLDN1/ ILVASC antibody for FACS & in-vivo assay
Go to CLDN1/CLDN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0271-Ab-1/ GM-Tg-hg-MP0271-Ab-2 | Anti-Human CLDN1 monoclonal antibody | Human |
| GM-Tg-rg-MP0271-Ab-1/ GM-Tg-rg-MP0271-Ab-2 | Anti-Rat CLDN1 monoclonal antibody | Rat |
| GM-Tg-mg-MP0271-Ab-1/ GM-Tg-mg-MP0271-Ab-2 | Anti-Mouse CLDN1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0271-Ab-1/ GM-Tg-cynog-MP0271-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CLDN1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0271-Ab-1/ GM-Tg-felg-MP0271-Ab-2 | Anti-Feline CLDN1 monoclonal antibody | Feline |
| GM-Tg-cang-MP0271-Ab-1/ GM-Tg-cang-MP0271-Ab-2 | Anti-Canine CLDN1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0271-Ab-1/ GM-Tg-bovg-MP0271-Ab-2 | Anti-Bovine CLDN1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0271-Ab-1/ GM-Tg-equg-MP0271-Ab-2 | Anti-Equine CLDN1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0271-Ab-1/ GM-Tg-hg-MP0271-Ab-2; GM-Tg-rg-MP0271-Ab-1/ GM-Tg-rg-MP0271-Ab-2; GM-Tg-mg-MP0271-Ab-1/ GM-Tg-mg-MP0271-Ab-2; GM-Tg-cynog-MP0271-Ab-1/ GM-Tg-cynog-MP0271-Ab-2; GM-Tg-felg-MP0271-Ab-1/ GM-Tg-felg-MP0271-Ab-2; GM-Tg-cang-MP0271-Ab-1/ GM-Tg-cang-MP0271-Ab-2; GM-Tg-bovg-MP0271-Ab-1/ GM-Tg-bovg-MP0271-Ab-2; GM-Tg-equg-MP0271-Ab-1/ GM-Tg-equg-MP0271-Ab-2 |
| Products Name | Anti-CLDN1 monoclonal antibody |
| Format | mab |
| Target Name | CLDN1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CLDN1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CLD1/ CLDN1/ ILVASC VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLV000077 | human CLDN1 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000077 | human CLDN1 Lentivirus particle |
| ORF Viral Vector | pGMLPm003689 | mouse Cldn1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003689 | mouse Cldn1 Lentivirus particle |
Target information
| Target ID | GM-MP0271 |
| Target Name | CLDN1 |
| Gene ID | 9076,12737,65129,704330,608207,101094619,414922,100059811 |
| Gene Symbol and Synonyms | claudin-1,CLD1,CLDN1,ILVASC,SEMP1 |
| Uniprot Accession | O95832,P56745,Q6L708 |
| Uniprot Entry Name | CLD1_HUMAN,CLD1_RAT,CLD1_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000163347 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: CLDN1, gene name: CLDN1, also named as CLD1, ILVASC, SEMP1. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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