Anti-CLD14/ CLDN14/ DFNB29 monoclonal antibody

Anti-CLD14/ CLDN14/ DFNB29 antibody for FACS & in-vivo assay

Target products collectionGo to CLDN14/CLDN14 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0274-Ab-1/ GM-Tg-hg-MP0274-Ab-2Anti-Human CLDN14 monoclonal antibodyHuman
GM-Tg-rg-MP0274-Ab-1/ GM-Tg-rg-MP0274-Ab-2Anti-Rat CLDN14 monoclonal antibodyRat
GM-Tg-mg-MP0274-Ab-1/ GM-Tg-mg-MP0274-Ab-2Anti-Mouse CLDN14 monoclonal antibodyMouse
GM-Tg-cynog-MP0274-Ab-1/ GM-Tg-cynog-MP0274-Ab-2Anti-Cynomolgus/ Rhesus macaque CLDN14 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0274-Ab-1/ GM-Tg-felg-MP0274-Ab-2Anti-Feline CLDN14 monoclonal antibodyFeline
GM-Tg-cang-MP0274-Ab-1/ GM-Tg-cang-MP0274-Ab-2Anti-Canine CLDN14 monoclonal antibodyCanine
GM-Tg-bovg-MP0274-Ab-1/ GM-Tg-bovg-MP0274-Ab-2Anti-Bovine CLDN14 monoclonal antibodyBovine
GM-Tg-equg-MP0274-Ab-1/ GM-Tg-equg-MP0274-Ab-2Anti-Equine CLDN14 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0274-Ab-1/ GM-Tg-hg-MP0274-Ab-2; GM-Tg-rg-MP0274-Ab-1/ GM-Tg-rg-MP0274-Ab-2;
GM-Tg-mg-MP0274-Ab-1/ GM-Tg-mg-MP0274-Ab-2; GM-Tg-cynog-MP0274-Ab-1/ GM-Tg-cynog-MP0274-Ab-2;
GM-Tg-felg-MP0274-Ab-1/ GM-Tg-felg-MP0274-Ab-2; GM-Tg-cang-MP0274-Ab-1/ GM-Tg-cang-MP0274-Ab-2;
GM-Tg-bovg-MP0274-Ab-1/ GM-Tg-bovg-MP0274-Ab-2; GM-Tg-equg-MP0274-Ab-1/ GM-Tg-equg-MP0274-Ab-2
Products NameAnti-CLDN14 monoclonal antibody
Formatmab
Target NameCLDN14
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CLDN14 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CLD14/ CLDN14/ DFNB29 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0274
    Target NameCLDN14
    Gene ID23562,56173,304073,695087,487751,101082083,783180,100051767
    Gene Symbol and SynonymsCLDN14,DFNB29
    Uniprot AccessionO95500
    Uniprot Entry NameCLD14_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000159261
    Target ClassificationN/A

    The target: CLDN14, gene name: CLDN14, also named as DFNB29. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.