Anti-CLD22/ CLDN22/ CLDN21 monoclonal antibody

Anti-CLD22/ CLDN22/ CLDN21 antibody for FACS & in-vivo assay

Target products collectionGo to CLDN22/CLDN22 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0281-Ab-1/ GM-Tg-hg-MP0281-Ab-2Anti-Human CLDN22 monoclonal antibodyHuman
GM-Tg-rg-MP0281-Ab-1/ GM-Tg-rg-MP0281-Ab-2Anti-Rat CLDN22 monoclonal antibodyRat
GM-Tg-mg-MP0281-Ab-1/ GM-Tg-mg-MP0281-Ab-2Anti-Mouse CLDN22 monoclonal antibodyMouse
GM-Tg-cynog-MP0281-Ab-1/ GM-Tg-cynog-MP0281-Ab-2Anti-Cynomolgus/ Rhesus macaque CLDN22 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0281-Ab-1/ GM-Tg-felg-MP0281-Ab-2Anti-Feline CLDN22 monoclonal antibodyFeline
GM-Tg-cang-MP0281-Ab-1/ GM-Tg-cang-MP0281-Ab-2Anti-Canine CLDN22 monoclonal antibodyCanine
GM-Tg-bovg-MP0281-Ab-1/ GM-Tg-bovg-MP0281-Ab-2Anti-Bovine CLDN22 monoclonal antibodyBovine
GM-Tg-equg-MP0281-Ab-1/ GM-Tg-equg-MP0281-Ab-2Anti-Equine CLDN22 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0281-Ab-1/ GM-Tg-hg-MP0281-Ab-2; GM-Tg-rg-MP0281-Ab-1/ GM-Tg-rg-MP0281-Ab-2;
GM-Tg-mg-MP0281-Ab-1/ GM-Tg-mg-MP0281-Ab-2; GM-Tg-cynog-MP0281-Ab-1/ GM-Tg-cynog-MP0281-Ab-2;
GM-Tg-felg-MP0281-Ab-1/ GM-Tg-felg-MP0281-Ab-2; GM-Tg-cang-MP0281-Ab-1/ GM-Tg-cang-MP0281-Ab-2;
GM-Tg-bovg-MP0281-Ab-1/ GM-Tg-bovg-MP0281-Ab-2; GM-Tg-equg-MP0281-Ab-1/ GM-Tg-equg-MP0281-Ab-2
Products NameAnti-CLDN22 monoclonal antibody
Formatmab
Target NameCLDN22
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CLDN22 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CLD22/ CLDN22/ CLDN21 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0281
    Target NameCLDN22
    Gene ID53842
    Gene Symbol and SynonymsCLDN21,CLDN22
    Uniprot AccessionQ8N7P3
    Uniprot Entry NameCLD22_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000177300
    Target ClassificationN/A

    The target: CLDN22, gene name: CLDN22, also named as CLDN21. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and overlaps the 3' UTR of the WWC2 gene (GeneID: 80014) on the opposite strand. [provided by RefSeq, Aug 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.