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Anti-CLD8/ CLDN8/ HEL-S-79 monoclonal antibody
Anti-CLD8/ CLDN8/ HEL-S-79 antibody for FACS & in-vivo assay
Go to CLDN8/CLDN8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0287-Ab-1/ GM-Tg-hg-MP0287-Ab-2 | Anti-Human CLDN8 monoclonal antibody | Human |
| GM-Tg-rg-MP0287-Ab-1/ GM-Tg-rg-MP0287-Ab-2 | Anti-Rat CLDN8 monoclonal antibody | Rat |
| GM-Tg-mg-MP0287-Ab-1/ GM-Tg-mg-MP0287-Ab-2 | Anti-Mouse CLDN8 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0287-Ab-1/ GM-Tg-cynog-MP0287-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CLDN8 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0287-Ab-1/ GM-Tg-felg-MP0287-Ab-2 | Anti-Feline CLDN8 monoclonal antibody | Feline |
| GM-Tg-cang-MP0287-Ab-1/ GM-Tg-cang-MP0287-Ab-2 | Anti-Canine CLDN8 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0287-Ab-1/ GM-Tg-bovg-MP0287-Ab-2 | Anti-Bovine CLDN8 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0287-Ab-1/ GM-Tg-equg-MP0287-Ab-2 | Anti-Equine CLDN8 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0287-Ab-1/ GM-Tg-hg-MP0287-Ab-2; GM-Tg-rg-MP0287-Ab-1/ GM-Tg-rg-MP0287-Ab-2; GM-Tg-mg-MP0287-Ab-1/ GM-Tg-mg-MP0287-Ab-2; GM-Tg-cynog-MP0287-Ab-1/ GM-Tg-cynog-MP0287-Ab-2; GM-Tg-felg-MP0287-Ab-1/ GM-Tg-felg-MP0287-Ab-2; GM-Tg-cang-MP0287-Ab-1/ GM-Tg-cang-MP0287-Ab-2; GM-Tg-bovg-MP0287-Ab-1/ GM-Tg-bovg-MP0287-Ab-2; GM-Tg-equg-MP0287-Ab-1/ GM-Tg-equg-MP0287-Ab-2 |
| Products Name | Anti-CLDN8 monoclonal antibody |
| Format | mab |
| Target Name | CLDN8 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CLDN8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CLD8/ CLDN8/ HEL-S-79 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0287 |
| Target Name | CLDN8 |
| Gene ID | 9073,54420,304124,705345,478401,101096909,538761,100053505 |
| Gene Symbol and Synonyms | Claudin-8,CLDN8,HEL-S-79 |
| Uniprot Accession | P56748 |
| Uniprot Entry Name | CLD8_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Prostate Cancer |
| Gene Ensembl | ENSG00000156284 |
| Target Classification | N/A |
The target: CLDN8, gene name: CLDN8, also named as HEL-S-79. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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