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Anti-CLC4G/ CLEC4G/ DTTR431 monoclonal antibody
Anti-CLC4G/ CLEC4G/ DTTR431 antibody for FACS & in-vivo assay
Go to CLEC4G/CLEC4G products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0299-Ab-1/ GM-Tg-hg-MP0299-Ab-2 | Anti-Human CLEC4G monoclonal antibody | Human |
| GM-Tg-rg-MP0299-Ab-1/ GM-Tg-rg-MP0299-Ab-2 | Anti-Rat CLEC4G monoclonal antibody | Rat |
| GM-Tg-mg-MP0299-Ab-1/ GM-Tg-mg-MP0299-Ab-2 | Anti-Mouse CLEC4G monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0299-Ab-1/ GM-Tg-cynog-MP0299-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CLEC4G monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0299-Ab-1/ GM-Tg-felg-MP0299-Ab-2 | Anti-Feline CLEC4G monoclonal antibody | Feline |
| GM-Tg-cang-MP0299-Ab-1/ GM-Tg-cang-MP0299-Ab-2 | Anti-Canine CLEC4G monoclonal antibody | Canine |
| GM-Tg-bovg-MP0299-Ab-1/ GM-Tg-bovg-MP0299-Ab-2 | Anti-Bovine CLEC4G monoclonal antibody | Bovine |
| GM-Tg-equg-MP0299-Ab-1/ GM-Tg-equg-MP0299-Ab-2 | Anti-Equine CLEC4G monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0299-Ab-1/ GM-Tg-hg-MP0299-Ab-2; GM-Tg-rg-MP0299-Ab-1/ GM-Tg-rg-MP0299-Ab-2; GM-Tg-mg-MP0299-Ab-1/ GM-Tg-mg-MP0299-Ab-2; GM-Tg-cynog-MP0299-Ab-1/ GM-Tg-cynog-MP0299-Ab-2; GM-Tg-felg-MP0299-Ab-1/ GM-Tg-felg-MP0299-Ab-2; GM-Tg-cang-MP0299-Ab-1/ GM-Tg-cang-MP0299-Ab-2; GM-Tg-bovg-MP0299-Ab-1/ GM-Tg-bovg-MP0299-Ab-2; GM-Tg-equg-MP0299-Ab-1/ GM-Tg-equg-MP0299-Ab-2 |
| Products Name | Anti-CLEC4G monoclonal antibody |
| Format | mab |
| Target Name | CLEC4G |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CLEC4G benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CLC4G/ CLEC4G/ DTTR431 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0299 |
| Target Name | CLEC4G |
| Gene ID | 339390,75863,689004,704872,484999,101096037,507332 |
| Gene Symbol and Synonyms | 4930572L20Rik,CLEC4G,DTTR431,LP2698,LSECtin,RGD1562320,UNQ431 |
| Uniprot Accession | Q6UXB4 |
| Uniprot Entry Name | CLC4G_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000182566 |
| Target Classification | N/A |
The target: CLEC4G, gene name: CLEC4G, also named as DTTR431, LP2698, LSECtin, UNQ431. This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the immune response. C-type lectin receptors are pattern recognition receptors located on immune cells that play a role in the recognition and uptake of both self and non-self glycoproteins as well as mediating cell adhesion, glycoprotein clearance, and cell signaling functions. This gene's protein binds complex-type N-glycans of the viral envelope proteins of Ebola virus, West Nile filovirus, and SARS coronavirus, but not HIV or hepatitis C virus. In mouse, this protein has been shown to recognize activated T-cells and to negatively regulate T-cell receptor-mediated signalling. It also acts as a novel, liver-specific regulator of NK cell-mediated immunity in mouse. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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