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Anti-CLN3/ BTN1/ BTS monoclonal antibody
Anti-CLN3/ BTN1/ BTS antibody for FACS & in-vivo assay
Go to CLN3/CLN3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0305-Ab-1/ GM-Tg-hg-MP0305-Ab-2 | Anti-Human CLN3 monoclonal antibody | Human |
| GM-Tg-rg-MP0305-Ab-1/ GM-Tg-rg-MP0305-Ab-2 | Anti-Rat CLN3 monoclonal antibody | Rat |
| GM-Tg-mg-MP0305-Ab-1/ GM-Tg-mg-MP0305-Ab-2 | Anti-Mouse CLN3 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0305-Ab-1/ GM-Tg-cynog-MP0305-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CLN3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0305-Ab-1/ GM-Tg-felg-MP0305-Ab-2 | Anti-Feline CLN3 monoclonal antibody | Feline |
| GM-Tg-cang-MP0305-Ab-1/ GM-Tg-cang-MP0305-Ab-2 | Anti-Canine CLN3 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0305-Ab-1/ GM-Tg-bovg-MP0305-Ab-2 | Anti-Bovine CLN3 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0305-Ab-1/ GM-Tg-equg-MP0305-Ab-2 | Anti-Equine CLN3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0305-Ab-1/ GM-Tg-hg-MP0305-Ab-2; GM-Tg-rg-MP0305-Ab-1/ GM-Tg-rg-MP0305-Ab-2; GM-Tg-mg-MP0305-Ab-1/ GM-Tg-mg-MP0305-Ab-2; GM-Tg-cynog-MP0305-Ab-1/ GM-Tg-cynog-MP0305-Ab-2; GM-Tg-felg-MP0305-Ab-1/ GM-Tg-felg-MP0305-Ab-2; GM-Tg-cang-MP0305-Ab-1/ GM-Tg-cang-MP0305-Ab-2; GM-Tg-bovg-MP0305-Ab-1/ GM-Tg-bovg-MP0305-Ab-2; GM-Tg-equg-MP0305-Ab-1/ GM-Tg-equg-MP0305-Ab-2 |
| Products Name | Anti-CLN3 monoclonal antibody |
| Format | mab |
| Target Name | CLN3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CLN3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CLN3/ BTN1/ BTS VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP002059 | human CLN3 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002059 | human CLN3 Lentivirus particle |
| ORF Viral Vector | pGMLPm004912 | mouse Cln3 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004912 | mouse Cln3 Lentivirus particle |
Target information
| Target ID | GM-MP0305 |
| Target Name | CLN3 |
| Gene ID | 1201,12752,293485,705815,479794,101089821,504799,100064282 |
| Gene Symbol and Synonyms | battenin,BTN1,BTS,CLN3,JNCL |
| Uniprot Accession | Q13286,Q29611 |
| Uniprot Entry Name | CLN3_HUMAN,CLN3_CANLF |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000188603 |
| Target Classification | N/A |
The target: CLN3, gene name: CLN3, also named as BTN1, BTS, JNCL. This gene encodes a protein that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs). Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
