Anti-CNNM2/ ACDP2/ HOMG6 monoclonal antibody

Anti-CNNM2/ ACDP2/ HOMG6 antibody for FACS & in-vivo assay

Target products collectionGo to CNNM2/CNNM2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0311-Ab-1/ GM-Tg-hg-MP0311-Ab-2Anti-Human CNNM2 monoclonal antibodyHuman
GM-Tg-rg-MP0311-Ab-1/ GM-Tg-rg-MP0311-Ab-2Anti-Rat CNNM2 monoclonal antibodyRat
GM-Tg-mg-MP0311-Ab-1/ GM-Tg-mg-MP0311-Ab-2Anti-Mouse CNNM2 monoclonal antibodyMouse
GM-Tg-cynog-MP0311-Ab-1/ GM-Tg-cynog-MP0311-Ab-2Anti-Cynomolgus/ Rhesus macaque CNNM2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0311-Ab-1/ GM-Tg-felg-MP0311-Ab-2Anti-Feline CNNM2 monoclonal antibodyFeline
GM-Tg-cang-MP0311-Ab-1/ GM-Tg-cang-MP0311-Ab-2Anti-Canine CNNM2 monoclonal antibodyCanine
GM-Tg-bovg-MP0311-Ab-1/ GM-Tg-bovg-MP0311-Ab-2Anti-Bovine CNNM2 monoclonal antibodyBovine
GM-Tg-equg-MP0311-Ab-1/ GM-Tg-equg-MP0311-Ab-2Anti-Equine CNNM2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0311-Ab-1/ GM-Tg-hg-MP0311-Ab-2; GM-Tg-rg-MP0311-Ab-1/ GM-Tg-rg-MP0311-Ab-2;
GM-Tg-mg-MP0311-Ab-1/ GM-Tg-mg-MP0311-Ab-2; GM-Tg-cynog-MP0311-Ab-1/ GM-Tg-cynog-MP0311-Ab-2;
GM-Tg-felg-MP0311-Ab-1/ GM-Tg-felg-MP0311-Ab-2; GM-Tg-cang-MP0311-Ab-1/ GM-Tg-cang-MP0311-Ab-2;
GM-Tg-bovg-MP0311-Ab-1/ GM-Tg-bovg-MP0311-Ab-2; GM-Tg-equg-MP0311-Ab-1/ GM-Tg-equg-MP0311-Ab-2
Products NameAnti-CNNM2 monoclonal antibody
Formatmab
Target NameCNNM2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CNNM2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CNNM2/ ACDP2/ HOMG6 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0311
    Target NameCNNM2
    Gene ID54805,94219,294014,714238,486866,101083369,504632,100059801
    Gene Symbol and SynonymsACDP2,Clp2,CNNM2,HOMG6,HOMGSMR
    Uniprot AccessionQ9H8M5,Q5U2P1
    Uniprot Entry NameCNNM2_HUMAN,CNNM2_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000148842
    Target ClassificationN/A

    The target: CNNM2, gene name: CNNM2, also named as ACDP2, HOMG6, HOMGSMR. This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play an important role in magnesium homeostasis by mediating the epithelial transport and renal reabsorption of Mg2+. Mutations in this gene are associated with renal hypomagnesemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.