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Anti-CNST/ C1orf71/ PPP1R64 monoclonal antibody
Anti-CNST/ C1orf71/ PPP1R64 antibody for FACS & in-vivo assay
Go to CNST/CNST products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0314-Ab-1/ GM-Tg-hg-MP0314-Ab-2 | Anti-Human CNST monoclonal antibody | Human |
| GM-Tg-rg-MP0314-Ab-1/ GM-Tg-rg-MP0314-Ab-2 | Anti-Rat CNST monoclonal antibody | Rat |
| GM-Tg-mg-MP0314-Ab-1/ GM-Tg-mg-MP0314-Ab-2 | Anti-Mouse CNST monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0314-Ab-1/ GM-Tg-cynog-MP0314-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CNST monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0314-Ab-1/ GM-Tg-felg-MP0314-Ab-2 | Anti-Feline CNST monoclonal antibody | Feline |
| GM-Tg-cang-MP0314-Ab-1/ GM-Tg-cang-MP0314-Ab-2 | Anti-Canine CNST monoclonal antibody | Canine |
| GM-Tg-bovg-MP0314-Ab-1/ GM-Tg-bovg-MP0314-Ab-2 | Anti-Bovine CNST monoclonal antibody | Bovine |
| GM-Tg-equg-MP0314-Ab-1/ GM-Tg-equg-MP0314-Ab-2 | Anti-Equine CNST monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0314-Ab-1/ GM-Tg-hg-MP0314-Ab-2; GM-Tg-rg-MP0314-Ab-1/ GM-Tg-rg-MP0314-Ab-2; GM-Tg-mg-MP0314-Ab-1/ GM-Tg-mg-MP0314-Ab-2; GM-Tg-cynog-MP0314-Ab-1/ GM-Tg-cynog-MP0314-Ab-2; GM-Tg-felg-MP0314-Ab-1/ GM-Tg-felg-MP0314-Ab-2; GM-Tg-cang-MP0314-Ab-1/ GM-Tg-cang-MP0314-Ab-2; GM-Tg-bovg-MP0314-Ab-1/ GM-Tg-bovg-MP0314-Ab-2; GM-Tg-equg-MP0314-Ab-1/ GM-Tg-equg-MP0314-Ab-2 |
| Products Name | Anti-CNST monoclonal antibody |
| Format | mab |
| Target Name | CNST |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CNST benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CNST/ C1orf71/ PPP1R64 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0314 |
| Target Name | CNST |
| Gene ID | 163882,226744,498297,711764,611848,101088971,541076,100054634 |
| Gene Symbol and Synonyms | 9630058J23Rik,C1orf71,CNST,PPP1R64,RGD1564833 |
| Uniprot Accession | Q6PJW8 |
| Uniprot Entry Name | CNST_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000162852 |
| Target Classification | N/A |
The target: CNST, gene name: CNST, also named as C1orf71, PPP1R64. Targeting of numerous transmembrane proteins to the cell surface is thought to depend on their recognition by cargo receptors that interact with the adaptor machinery for anterograde traffic at the distal end of the Golgi complex. Consortin (CNST) is an integral membrane protein that acts as a binding partner of connexins, the building blocks of gap junctions, and acts as a trans-Golgi network (TGN) receptor involved in connexin targeting to the plasma membrane and recycling from the cell surface (del Castillo et al., 2010 [PubMed 19864490]).[supplied by OMIM, Jun 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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