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Anti-COHA1/ COL17A1/ BA16H23.2 monoclonal antibody
Anti-COHA1/ COL17A1/ BA16H23.2 antibody for FACS & in-vivo assay
Go to COL17A1/COL17A1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0323-Ab-1/ GM-Tg-hg-MP0323-Ab-2 | Anti-Human COL17A1 monoclonal antibody | Human |
| GM-Tg-rg-MP0323-Ab-1/ GM-Tg-rg-MP0323-Ab-2 | Anti-Rat COL17A1 monoclonal antibody | Rat |
| GM-Tg-mg-MP0323-Ab-1/ GM-Tg-mg-MP0323-Ab-2 | Anti-Mouse COL17A1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0323-Ab-1/ GM-Tg-cynog-MP0323-Ab-2 | Anti-Cynomolgus/ Rhesus macaque COL17A1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0323-Ab-1/ GM-Tg-felg-MP0323-Ab-2 | Anti-Feline COL17A1 monoclonal antibody | Feline |
| GM-Tg-cang-MP0323-Ab-1/ GM-Tg-cang-MP0323-Ab-2 | Anti-Canine COL17A1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0323-Ab-1/ GM-Tg-bovg-MP0323-Ab-2 | Anti-Bovine COL17A1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0323-Ab-1/ GM-Tg-equg-MP0323-Ab-2 | Anti-Equine COL17A1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0323-Ab-1/ GM-Tg-hg-MP0323-Ab-2; GM-Tg-rg-MP0323-Ab-1/ GM-Tg-rg-MP0323-Ab-2; GM-Tg-mg-MP0323-Ab-1/ GM-Tg-mg-MP0323-Ab-2; GM-Tg-cynog-MP0323-Ab-1/ GM-Tg-cynog-MP0323-Ab-2; GM-Tg-felg-MP0323-Ab-1/ GM-Tg-felg-MP0323-Ab-2; GM-Tg-cang-MP0323-Ab-1/ GM-Tg-cang-MP0323-Ab-2; GM-Tg-bovg-MP0323-Ab-1/ GM-Tg-bovg-MP0323-Ab-2; GM-Tg-equg-MP0323-Ab-1/ GM-Tg-equg-MP0323-Ab-2 |
| Products Name | Anti-COL17A1 monoclonal antibody |
| Format | mab |
| Target Name | COL17A1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-COL17A1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species COHA1/ COL17A1/ BA16H23.2 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0323 |
| Target Name | COL17A1 |
| Gene ID | 1308,12821,294027,403739,101096849,513804,100069671 |
| Gene Symbol and Synonyms | BA16H23.2,BP180,BPA-2,Bpag,BPAG2,COL17A1,ERED,JEB4,LAD-1 |
| Uniprot Accession | Q9UMD9,Q9N281,A6QPB3 |
| Uniprot Entry Name | COHA1_HUMAN,COHA1_CANLF,COHA1_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000065618 |
| Target Classification | N/A |
The target: COL17A1, gene name: COL17A1, also named as BA16H23.2, BP180, BPA-2, BPAG2, ERED, LAD-1. This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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