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Anti-COL12/ COLEC12/ CLP1 monoclonal antibody
Anti-COL12/ COLEC12/ CLP1 antibody for FACS & in-vivo assay
Go to COLEC12/COLEC12 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0326-Ab-1/ GM-Tg-hg-MP0326-Ab-2 | Anti-Human COLEC12 monoclonal antibody | Human |
| GM-Tg-rg-MP0326-Ab-1/ GM-Tg-rg-MP0326-Ab-2 | Anti-Rat COLEC12 monoclonal antibody | Rat |
| GM-Tg-mg-MP0326-Ab-1/ GM-Tg-mg-MP0326-Ab-2 | Anti-Mouse COLEC12 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0326-Ab-1/ GM-Tg-cynog-MP0326-Ab-2 | Anti-Cynomolgus/ Rhesus macaque COLEC12 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0326-Ab-1/ GM-Tg-felg-MP0326-Ab-2 | Anti-Feline COLEC12 monoclonal antibody | Feline |
| GM-Tg-cang-MP0326-Ab-1/ GM-Tg-cang-MP0326-Ab-2 | Anti-Canine COLEC12 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0326-Ab-1/ GM-Tg-bovg-MP0326-Ab-2 | Anti-Bovine COLEC12 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0326-Ab-1/ GM-Tg-equg-MP0326-Ab-2 | Anti-Equine COLEC12 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0326-Ab-1/ GM-Tg-hg-MP0326-Ab-2; GM-Tg-rg-MP0326-Ab-1/ GM-Tg-rg-MP0326-Ab-2; GM-Tg-mg-MP0326-Ab-1/ GM-Tg-mg-MP0326-Ab-2; GM-Tg-cynog-MP0326-Ab-1/ GM-Tg-cynog-MP0326-Ab-2; GM-Tg-felg-MP0326-Ab-1/ GM-Tg-felg-MP0326-Ab-2; GM-Tg-cang-MP0326-Ab-1/ GM-Tg-cang-MP0326-Ab-2; GM-Tg-bovg-MP0326-Ab-1/ GM-Tg-bovg-MP0326-Ab-2; GM-Tg-equg-MP0326-Ab-1/ GM-Tg-equg-MP0326-Ab-2 |
| Products Name | Anti-COLEC12 monoclonal antibody |
| Format | mab |
| Target Name | COLEC12 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-COLEC12 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species COL12/ COLEC12/ CLP1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP001333 | human COLEC12 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001333 | human COLEC12 Lentivirus particle |
Target information
| Target ID | GM-MP0326 |
| Target Name | COLEC12 |
| Gene ID | 81035,140792,361289,700031,607342,101094054,504741,100060744 |
| Gene Symbol and Synonyms | CL-P1,CLP1,COLEC12,NSR2,SCARA4,SRCL |
| Uniprot Accession | Q5KU26,Q4V885,A6QP79 |
| Uniprot Entry Name | COL12_HUMAN,COL12_RAT,COL12_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000158270 |
| Target Classification | N/A |
The target: COLEC12, gene name: COLEC12, also named as CLP1, NSR2, SCARA4, SRCL. This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells. [provided by RefSeq, May 2018].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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