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Anti-CRUM1/ CRB1/ LCA8 monoclonal antibody
Anti-CRUM1/ CRB1/ LCA8 antibody for FACS & in-vivo assay
Go to CRB1/CRB1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0331-Ab-1/ GM-Tg-hg-MP0331-Ab-2 | Anti-Human CRB1 monoclonal antibody | Human |
| GM-Tg-rg-MP0331-Ab-1/ GM-Tg-rg-MP0331-Ab-2 | Anti-Rat CRB1 monoclonal antibody | Rat |
| GM-Tg-mg-MP0331-Ab-1/ GM-Tg-mg-MP0331-Ab-2 | Anti-Mouse CRB1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0331-Ab-1/ GM-Tg-cynog-MP0331-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CRB1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0331-Ab-1/ GM-Tg-felg-MP0331-Ab-2 | Anti-Feline CRB1 monoclonal antibody | Feline |
| GM-Tg-cang-MP0331-Ab-1/ GM-Tg-cang-MP0331-Ab-2 | Anti-Canine CRB1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0331-Ab-1/ GM-Tg-bovg-MP0331-Ab-2 | Anti-Bovine CRB1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0331-Ab-1/ GM-Tg-equg-MP0331-Ab-2 | Anti-Equine CRB1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0331-Ab-1/ GM-Tg-hg-MP0331-Ab-2; GM-Tg-rg-MP0331-Ab-1/ GM-Tg-rg-MP0331-Ab-2; GM-Tg-mg-MP0331-Ab-1/ GM-Tg-mg-MP0331-Ab-2; GM-Tg-cynog-MP0331-Ab-1/ GM-Tg-cynog-MP0331-Ab-2; GM-Tg-felg-MP0331-Ab-1/ GM-Tg-felg-MP0331-Ab-2; GM-Tg-cang-MP0331-Ab-1/ GM-Tg-cang-MP0331-Ab-2; GM-Tg-bovg-MP0331-Ab-1/ GM-Tg-bovg-MP0331-Ab-2; GM-Tg-equg-MP0331-Ab-1/ GM-Tg-equg-MP0331-Ab-2 |
| Products Name | Anti-CRB1 monoclonal antibody |
| Format | mab |
| Target Name | CRB1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CRB1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CRUM1/ CRB1/ LCA8 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0331 |
| Target Name | CRB1 |
| Gene ID | 23418,170788,304825,710991,490260,101092328,520406,100061068 |
| Gene Symbol and Synonyms | 7530426H14Rik,A930008G09Rik,CRB1,CRB1-A,CRB1-A2,CRB1-B,CRB1-C,LCA8,RP12 |
| Uniprot Accession | P82279 |
| Uniprot Entry Name | CRUM1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000134376 |
| Target Classification | N/A |
The target: CRB1, gene name: CRB1, also named as LCA8, RP12. This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis. Alternate splicing results in multiple transcript variants, some protein coding and some non-protein coding.[provided by RefSeq, Apr 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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