Anti-CRUM2/ CRB2/ FSGS9 monoclonal antibody

Anti-CRUM2/ CRB2/ FSGS9 antibody for FACS & in-vivo assay

Target products collectionGo to CRB2/CRB2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0332-Ab-1/ GM-Tg-hg-MP0332-Ab-2Anti-Human CRB2 monoclonal antibodyHuman
GM-Tg-rg-MP0332-Ab-1/ GM-Tg-rg-MP0332-Ab-2Anti-Rat CRB2 monoclonal antibodyRat
GM-Tg-mg-MP0332-Ab-1/ GM-Tg-mg-MP0332-Ab-2Anti-Mouse CRB2 monoclonal antibodyMouse
GM-Tg-cynog-MP0332-Ab-1/ GM-Tg-cynog-MP0332-Ab-2Anti-Cynomolgus/ Rhesus macaque CRB2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0332-Ab-1/ GM-Tg-felg-MP0332-Ab-2Anti-Feline CRB2 monoclonal antibodyFeline
GM-Tg-cang-MP0332-Ab-1/ GM-Tg-cang-MP0332-Ab-2Anti-Canine CRB2 monoclonal antibodyCanine
GM-Tg-bovg-MP0332-Ab-1/ GM-Tg-bovg-MP0332-Ab-2Anti-Bovine CRB2 monoclonal antibodyBovine
GM-Tg-equg-MP0332-Ab-1/ GM-Tg-equg-MP0332-Ab-2Anti-Equine CRB2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0332-Ab-1/ GM-Tg-hg-MP0332-Ab-2; GM-Tg-rg-MP0332-Ab-1/ GM-Tg-rg-MP0332-Ab-2;
GM-Tg-mg-MP0332-Ab-1/ GM-Tg-mg-MP0332-Ab-2; GM-Tg-cynog-MP0332-Ab-1/ GM-Tg-cynog-MP0332-Ab-2;
GM-Tg-felg-MP0332-Ab-1/ GM-Tg-felg-MP0332-Ab-2; GM-Tg-cang-MP0332-Ab-1/ GM-Tg-cang-MP0332-Ab-2;
GM-Tg-bovg-MP0332-Ab-1/ GM-Tg-bovg-MP0332-Ab-2; GM-Tg-equg-MP0332-Ab-1/ GM-Tg-equg-MP0332-Ab-2
Products NameAnti-CRB2 monoclonal antibody
Formatmab
Target NameCRB2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CRB2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CRUM2/ CRB2/ FSGS9 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0332
    Target NameCRB2
    Gene ID286204,241324,366031,695065,491341,101088123,786516,100146515
    Gene Symbol and Synonyms5930402A21,CRB2,FSGS9,RGD1309368,VMCKD
    Uniprot AccessionQ5IJ48
    Uniprot Entry NameCRUM2_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000148204
    Target ClassificationN/A

    The target: CRB2, gene name: CRB2, also named as FSGS9, VMCKD. This gene encodes a member of a family of proteins that are components of the Crumbs cell polarity complex. In mammals, members of this family are thought to play a role in many cellular processes in early embryonic development. A similar protein in Drosophila determines apicobasal polarity in embryonic epithelial cells. Mutations in this gene are associated with focal segmental glomerulosclerosis 9, and with ventriculomegaly with cystic kidney disease. [provided by RefSeq, Aug 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.