Anti-CTNS/ CTNS-LSB/ PQLC4 monoclonal antibody

Anti-CTNS/ CTNS-LSB/ PQLC4 antibody for FACS & in-vivo assay

Target products collectionGo to CTNS/CTNS products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0340-Ab-1/ GM-Tg-hg-MP0340-Ab-2Anti-Human CTNS monoclonal antibodyHuman
GM-Tg-rg-MP0340-Ab-1/ GM-Tg-rg-MP0340-Ab-2Anti-Rat CTNS monoclonal antibodyRat
GM-Tg-mg-MP0340-Ab-1/ GM-Tg-mg-MP0340-Ab-2Anti-Mouse CTNS monoclonal antibodyMouse
GM-Tg-cynog-MP0340-Ab-1/ GM-Tg-cynog-MP0340-Ab-2Anti-Cynomolgus/ Rhesus macaque CTNS monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0340-Ab-1/ GM-Tg-felg-MP0340-Ab-2Anti-Feline CTNS monoclonal antibodyFeline
GM-Tg-cang-MP0340-Ab-1/ GM-Tg-cang-MP0340-Ab-2Anti-Canine CTNS monoclonal antibodyCanine
GM-Tg-bovg-MP0340-Ab-1/ GM-Tg-bovg-MP0340-Ab-2Anti-Bovine CTNS monoclonal antibodyBovine
GM-Tg-equg-MP0340-Ab-1/ GM-Tg-equg-MP0340-Ab-2Anti-Equine CTNS monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0340-Ab-1/ GM-Tg-hg-MP0340-Ab-2; GM-Tg-rg-MP0340-Ab-1/ GM-Tg-rg-MP0340-Ab-2;
GM-Tg-mg-MP0340-Ab-1/ GM-Tg-mg-MP0340-Ab-2; GM-Tg-cynog-MP0340-Ab-1/ GM-Tg-cynog-MP0340-Ab-2;
GM-Tg-felg-MP0340-Ab-1/ GM-Tg-felg-MP0340-Ab-2; GM-Tg-cang-MP0340-Ab-1/ GM-Tg-cang-MP0340-Ab-2;
GM-Tg-bovg-MP0340-Ab-1/ GM-Tg-bovg-MP0340-Ab-2; GM-Tg-equg-MP0340-Ab-1/ GM-Tg-equg-MP0340-Ab-2
Products NameAnti-CTNS monoclonal antibody
Formatmab
Target NameCTNS
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CTNS benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CTNS/ CTNS-LSB/ PQLC4 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0340
    Target NameCTNS
    Gene ID1497,83429,287478,706721,100856090,101092308,613527,100060554
    Gene Symbol and SynonymsCTNS,CTNS-LSB,PQLC4,SLC66A4
    Uniprot AccessionO60931,A7MB63
    Uniprot Entry NameCTNS_HUMAN,CTNS_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000040531
    Target ClassificationN/A

    The target: CTNS, gene name: CTNS, also named as CTNS-LSB, PQLC4, SLC66A4. This gene encodes a seven-transmembrane domain protein that functions to transport cystine out of lysosomes. Its activity is driven by the H+ electrochemical gradient of the lysosomal membrane. Mutations in this gene cause cystinosis, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.