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Anti-CYH1/ CYTH1/ B2-1 monoclonal antibody
Anti-CYH1/ CYTH1/ B2-1 antibody for FACS & in-vivo assay
Go to CYTH1/CYTH1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0347-Ab-1/ GM-Tg-hg-MP0347-Ab-2 | Anti-Human CYTH1 monoclonal antibody | Human |
| GM-Tg-rg-MP0347-Ab-1/ GM-Tg-rg-MP0347-Ab-2 | Anti-Rat CYTH1 monoclonal antibody | Rat |
| GM-Tg-mg-MP0347-Ab-1/ GM-Tg-mg-MP0347-Ab-2 | Anti-Mouse CYTH1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0347-Ab-1/ GM-Tg-cynog-MP0347-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CYTH1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0347-Ab-1/ GM-Tg-felg-MP0347-Ab-2 | Anti-Feline CYTH1 monoclonal antibody | Feline |
| GM-Tg-cang-MP0347-Ab-1/ GM-Tg-cang-MP0347-Ab-2 | Anti-Canine CYTH1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0347-Ab-1/ GM-Tg-bovg-MP0347-Ab-2 | Anti-Bovine CYTH1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0347-Ab-1/ GM-Tg-equg-MP0347-Ab-2 | Anti-Equine CYTH1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0347-Ab-1/ GM-Tg-hg-MP0347-Ab-2; GM-Tg-rg-MP0347-Ab-1/ GM-Tg-rg-MP0347-Ab-2; GM-Tg-mg-MP0347-Ab-1/ GM-Tg-mg-MP0347-Ab-2; GM-Tg-cynog-MP0347-Ab-1/ GM-Tg-cynog-MP0347-Ab-2; GM-Tg-felg-MP0347-Ab-1/ GM-Tg-felg-MP0347-Ab-2; GM-Tg-cang-MP0347-Ab-1/ GM-Tg-cang-MP0347-Ab-2; GM-Tg-bovg-MP0347-Ab-1/ GM-Tg-bovg-MP0347-Ab-2; GM-Tg-equg-MP0347-Ab-1/ GM-Tg-equg-MP0347-Ab-2 |
| Products Name | Anti-CYTH1 monoclonal antibody |
| Format | mab |
| Target Name | CYTH1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CYTH1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CYH1/ CYTH1/ B2-1 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0347 |
| Target Name | CYTH1 |
| Gene ID | 9267,19157,116691,710305,608079,101082609,100141038,100057600 |
| Gene Symbol and Synonyms | B2-1,CLM1,CTH-1,CYTH1,CYTIP,CYTOHESIN-1,D17S811E,PSCD1,SEC7 |
| Uniprot Accession | Q15438,P97694 |
| Uniprot Entry Name | CYH1_HUMAN,CYH1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000108669 |
| Target Classification | N/A |
The target: CYTH1, gene name: CYTH1, also named as B2-1, CYTOHESIN-1, D17S811E, PSCD1, SEC7. The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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