Anti-DAPK1/ DAPK/ ROCO3 monoclonal antibody

Anti-DAPK1/ DAPK/ ROCO3 antibody for FACS & in-vivo assay

Target products collectionGo to DAPK1/DAPK1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0348-Ab-1/ GM-Tg-hg-MP0348-Ab-2Anti-Human DAPK1 monoclonal antibodyHuman
GM-Tg-rg-MP0348-Ab-1/ GM-Tg-rg-MP0348-Ab-2Anti-Rat DAPK1 monoclonal antibodyRat
GM-Tg-mg-MP0348-Ab-1/ GM-Tg-mg-MP0348-Ab-2Anti-Mouse DAPK1 monoclonal antibodyMouse
GM-Tg-cynog-MP0348-Ab-1/ GM-Tg-cynog-MP0348-Ab-2Anti-Cynomolgus/ Rhesus macaque DAPK1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0348-Ab-1/ GM-Tg-felg-MP0348-Ab-2Anti-Feline DAPK1 monoclonal antibodyFeline
GM-Tg-cang-MP0348-Ab-1/ GM-Tg-cang-MP0348-Ab-2Anti-Canine DAPK1 monoclonal antibodyCanine
GM-Tg-bovg-MP0348-Ab-1/ GM-Tg-bovg-MP0348-Ab-2Anti-Bovine DAPK1 monoclonal antibodyBovine
GM-Tg-equg-MP0348-Ab-1/ GM-Tg-equg-MP0348-Ab-2Anti-Equine DAPK1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0348-Ab-1/ GM-Tg-hg-MP0348-Ab-2; GM-Tg-rg-MP0348-Ab-1/ GM-Tg-rg-MP0348-Ab-2;
GM-Tg-mg-MP0348-Ab-1/ GM-Tg-mg-MP0348-Ab-2; GM-Tg-cynog-MP0348-Ab-1/ GM-Tg-cynog-MP0348-Ab-2;
GM-Tg-felg-MP0348-Ab-1/ GM-Tg-felg-MP0348-Ab-2; GM-Tg-cang-MP0348-Ab-1/ GM-Tg-cang-MP0348-Ab-2;
GM-Tg-bovg-MP0348-Ab-1/ GM-Tg-bovg-MP0348-Ab-2; GM-Tg-equg-MP0348-Ab-1/ GM-Tg-equg-MP0348-Ab-2
Products NameAnti-DAPK1 monoclonal antibody
Formatmab
Target NameDAPK1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-DAPK1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species DAPK1/ DAPK/ ROCO3 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0348
    Target NameDAPK1
    Gene ID1612,69635,306722,694315,484142,101084322,540873,100061567
    Gene Symbol and SynonymsD13Ucla1,DAP-Kinase,DAPK,DAPK1,ROCO3
    Uniprot AccessionP53355
    Uniprot Entry NameDAPK1_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseLung Cancer
    Gene EnsemblENSG00000196730
    Target ClassificationKinase

    The target: DAPK1, gene name: DAPK1, also named as DAPK, ROCO3. Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.