Anti-DCC/ CRC18/ CRCR1 monoclonal antibody

Anti-DCC/ CRC18/ CRCR1 antibody for FACS & in-vivo assay

Target products collectionGo to DCC/DCC products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0349-Ab-1/ GM-Tg-hg-MP0349-Ab-2Anti-Human DCC monoclonal antibodyHuman
GM-Tg-rg-MP0349-Ab-1/ GM-Tg-rg-MP0349-Ab-2Anti-Rat DCC monoclonal antibodyRat
GM-Tg-mg-MP0349-Ab-1/ GM-Tg-mg-MP0349-Ab-2Anti-Mouse DCC monoclonal antibodyMouse
GM-Tg-cynog-MP0349-Ab-1/ GM-Tg-cynog-MP0349-Ab-2Anti-Cynomolgus/ Rhesus macaque DCC monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0349-Ab-1/ GM-Tg-felg-MP0349-Ab-2Anti-Feline DCC monoclonal antibodyFeline
GM-Tg-cang-MP0349-Ab-1/ GM-Tg-cang-MP0349-Ab-2Anti-Canine DCC monoclonal antibodyCanine
GM-Tg-bovg-MP0349-Ab-1/ GM-Tg-bovg-MP0349-Ab-2Anti-Bovine DCC monoclonal antibodyBovine
GM-Tg-equg-MP0349-Ab-1/ GM-Tg-equg-MP0349-Ab-2Anti-Equine DCC monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0349-Ab-1/ GM-Tg-hg-MP0349-Ab-2; GM-Tg-rg-MP0349-Ab-1/ GM-Tg-rg-MP0349-Ab-2;
GM-Tg-mg-MP0349-Ab-1/ GM-Tg-mg-MP0349-Ab-2; GM-Tg-cynog-MP0349-Ab-1/ GM-Tg-cynog-MP0349-Ab-2;
GM-Tg-felg-MP0349-Ab-1/ GM-Tg-felg-MP0349-Ab-2; GM-Tg-cang-MP0349-Ab-1/ GM-Tg-cang-MP0349-Ab-2;
GM-Tg-bovg-MP0349-Ab-1/ GM-Tg-bovg-MP0349-Ab-2; GM-Tg-equg-MP0349-Ab-1/ GM-Tg-equg-MP0349-Ab-2
Products NameAnti-DCC monoclonal antibody
Formatmab
Target NameDCC
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-DCC benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species DCC/ CRC18/ CRCR1 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0349
    Target NameDCC
    Gene ID1630,13176,25311,693352,483976,101098832,537176,100054013
    Gene Symbol and SynonymsC030036D22Rik,CRC18,CRCR1,DCC,HGPPS2,IGDCC1,MRMV1,NTN1R1
    Uniprot AccessionP43146,Q63155
    Uniprot Entry NameDCC_HUMAN,DCC_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseColon cancer
    Gene EnsemblENSG00000187323
    Target ClassificationN/A

    The target: DCC, gene name: DCC, also named as CRC18, CRCR1, HGPPS2, IGDCC1, MRMV1, NTN1R1. This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.