Anti-DCC/ CRC18/ CRCR1 monoclonal antibody
Anti-DCC/ CRC18/ CRCR1 antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-MP0349-Ab-1/ GM-Tg-hg-MP0349-Ab-2 | Anti-Human DCC monoclonal antibody | Human |
GM-Tg-rg-MP0349-Ab-1/ GM-Tg-rg-MP0349-Ab-2 | Anti-Rat DCC monoclonal antibody | Rat |
GM-Tg-mg-MP0349-Ab-1/ GM-Tg-mg-MP0349-Ab-2 | Anti-Mouse DCC monoclonal antibody | Mouse |
GM-Tg-cynog-MP0349-Ab-1/ GM-Tg-cynog-MP0349-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DCC monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-MP0349-Ab-1/ GM-Tg-felg-MP0349-Ab-2 | Anti-Feline DCC monoclonal antibody | Feline |
GM-Tg-cang-MP0349-Ab-1/ GM-Tg-cang-MP0349-Ab-2 | Anti-Canine DCC monoclonal antibody | Canine |
GM-Tg-bovg-MP0349-Ab-1/ GM-Tg-bovg-MP0349-Ab-2 | Anti-Bovine DCC monoclonal antibody | Bovine |
GM-Tg-equg-MP0349-Ab-1/ GM-Tg-equg-MP0349-Ab-2 | Anti-Equine DCC monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-MP0349-Ab-1/ GM-Tg-hg-MP0349-Ab-2; GM-Tg-rg-MP0349-Ab-1/ GM-Tg-rg-MP0349-Ab-2; GM-Tg-mg-MP0349-Ab-1/ GM-Tg-mg-MP0349-Ab-2; GM-Tg-cynog-MP0349-Ab-1/ GM-Tg-cynog-MP0349-Ab-2; GM-Tg-felg-MP0349-Ab-1/ GM-Tg-felg-MP0349-Ab-2; GM-Tg-cang-MP0349-Ab-1/ GM-Tg-cang-MP0349-Ab-2; GM-Tg-bovg-MP0349-Ab-1/ GM-Tg-bovg-MP0349-Ab-2; GM-Tg-equg-MP0349-Ab-1/ GM-Tg-equg-MP0349-Ab-2 |
Products Name | Anti-DCC monoclonal antibody |
Format | mab |
Target Name | DCC |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-DCC benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species DCC/ CRC18/ CRCR1 VLP (virus-like particle) (Products Developing) |
Target information
Target ID | GM-MP0349 |
Target Name | DCC |
Gene ID | 1630,13176,25311,693352,483976,101098832,537176,100054013 |
Gene Symbol and Synonyms | C030036D22Rik,CRC18,CRCR1,DCC,HGPPS2,IGDCC1,MRMV1,NTN1R1 |
Uniprot Accession | P43146,Q63155 |
Uniprot Entry Name | DCC_HUMAN,DCC_RAT |
Protein Sub-location | Transmembrane Protein |
Category | |
Disease | Colon cancer |
Gene Ensembl | ENSG00000187323 |
Target Classification | N/A |
The target: DCC, gene name: DCC, also named as CRC18, CRCR1, HGPPS2, IGDCC1, MRMV1, NTN1R1. This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.