Anti-PCD23/ DCHS2/ CDH27 monoclonal antibody

Anti-PCD23/ DCHS2/ CDH27 antibody for FACS & in-vivo assay

Target products collectionGo to DCHS2/DCHS2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0350-Ab-1/ GM-Tg-hg-MP0350-Ab-2Anti-Human DCHS2 monoclonal antibodyHuman
GM-Tg-rg-MP0350-Ab-1/ GM-Tg-rg-MP0350-Ab-2Anti-Rat DCHS2 monoclonal antibodyRat
GM-Tg-mg-MP0350-Ab-1/ GM-Tg-mg-MP0350-Ab-2Anti-Mouse DCHS2 monoclonal antibodyMouse
GM-Tg-cynog-MP0350-Ab-1/ GM-Tg-cynog-MP0350-Ab-2Anti-Cynomolgus/ Rhesus macaque DCHS2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0350-Ab-1/ GM-Tg-felg-MP0350-Ab-2Anti-Feline DCHS2 monoclonal antibodyFeline
GM-Tg-cang-MP0350-Ab-1/ GM-Tg-cang-MP0350-Ab-2Anti-Canine DCHS2 monoclonal antibodyCanine
GM-Tg-bovg-MP0350-Ab-1/ GM-Tg-bovg-MP0350-Ab-2Anti-Bovine DCHS2 monoclonal antibodyBovine
GM-Tg-equg-MP0350-Ab-1/ GM-Tg-equg-MP0350-Ab-2Anti-Equine DCHS2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0350-Ab-1/ GM-Tg-hg-MP0350-Ab-2; GM-Tg-rg-MP0350-Ab-1/ GM-Tg-rg-MP0350-Ab-2;
GM-Tg-mg-MP0350-Ab-1/ GM-Tg-mg-MP0350-Ab-2; GM-Tg-cynog-MP0350-Ab-1/ GM-Tg-cynog-MP0350-Ab-2;
GM-Tg-felg-MP0350-Ab-1/ GM-Tg-felg-MP0350-Ab-2; GM-Tg-cang-MP0350-Ab-1/ GM-Tg-cang-MP0350-Ab-2;
GM-Tg-bovg-MP0350-Ab-1/ GM-Tg-bovg-MP0350-Ab-2; GM-Tg-equg-MP0350-Ab-1/ GM-Tg-equg-MP0350-Ab-2
Products NameAnti-DCHS2 monoclonal antibody
Formatmab
Target NameDCHS2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-DCHS2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species PCD23/ DCHS2/ CDH27 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0350
    Target NameDCHS2
    Gene ID54798,100534287,310550,697604,482659,101100127,539323,100069855
    Gene Symbol and SynonymsCDH27,CDHJ,CDHR7,DCHS2,EG627094,Gm417,Gm6731,PCDH23,PCDHJ,RGD1563329
    Uniprot AccessionQ6V1P9
    Uniprot Entry NamePCD23_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000197410
    Target ClassificationN/A

    The target: DCHS2, gene name: DCHS2, also named as CDH27, CDHJ, CDHR7, PCDH23, PCDHJ. This gene encodes a large protein that contains many cadherin domains and likely functions in cell adhesion. Genome-wide association studies suggest that this gene may be important in Alzheimer's disease, compressive strength index, and appendicular lean mass. [provided by RefSeq, May 2017].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.