Anti-OST48/ DDOST/ AGER1 monoclonal antibody

Anti-OST48/ DDOST/ AGER1 antibody for FACS & in-vivo assay

Target products collectionGo to DDOST/DDOST products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0354-Ab-1/ GM-Tg-hg-MP0354-Ab-2Anti-Human DDOST monoclonal antibodyHuman
GM-Tg-rg-MP0354-Ab-1/ GM-Tg-rg-MP0354-Ab-2Anti-Rat DDOST monoclonal antibodyRat
GM-Tg-mg-MP0354-Ab-1/ GM-Tg-mg-MP0354-Ab-2Anti-Mouse DDOST monoclonal antibodyMouse
GM-Tg-cynog-MP0354-Ab-1/ GM-Tg-cynog-MP0354-Ab-2Anti-Cynomolgus/ Rhesus macaque DDOST monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0354-Ab-1/ GM-Tg-felg-MP0354-Ab-2Anti-Feline DDOST monoclonal antibodyFeline
GM-Tg-cang-MP0354-Ab-1/ GM-Tg-cang-MP0354-Ab-2Anti-Canine DDOST monoclonal antibodyCanine
GM-Tg-bovg-MP0354-Ab-1/ GM-Tg-bovg-MP0354-Ab-2Anti-Bovine DDOST monoclonal antibodyBovine
GM-Tg-equg-MP0354-Ab-1/ GM-Tg-equg-MP0354-Ab-2Anti-Equine DDOST monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0354-Ab-1/ GM-Tg-hg-MP0354-Ab-2; GM-Tg-rg-MP0354-Ab-1/ GM-Tg-rg-MP0354-Ab-2;
GM-Tg-mg-MP0354-Ab-1/ GM-Tg-mg-MP0354-Ab-2; GM-Tg-cynog-MP0354-Ab-1/ GM-Tg-cynog-MP0354-Ab-2;
GM-Tg-felg-MP0354-Ab-1/ GM-Tg-felg-MP0354-Ab-2; GM-Tg-cang-MP0354-Ab-1/ GM-Tg-cang-MP0354-Ab-2;
GM-Tg-bovg-MP0354-Ab-1/ GM-Tg-bovg-MP0354-Ab-2; GM-Tg-equg-MP0354-Ab-1/ GM-Tg-equg-MP0354-Ab-2
Products NameAnti-DDOST monoclonal antibody
Formatmab
Target NameDDOST
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-DDOST benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species OST48/ DDOST/ AGER1 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0354
    Target NameDDOST
    Gene ID1650,13200,313648,706148,404012,101093032,510682,100071776
    Gene Symbol and SynonymsAGER1,CDG1R,DDOST,GATD6,OKSWcl45,OST,OST48,WBP1
    Uniprot AccessionP39656,Q641Y0,Q05052,A6QPY0
    Uniprot Entry NameOST48_HUMAN,OST48_RAT,OST48_CANLF,OST48_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000244038
    Target ClassificationN/A

    The target: DDOST, gene name: DDOST, also named as AGER1, CDG1R, GATD6, OKSWcl45, OST, OST48, WBP1. This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.