Anti-DEN4C/ DENND4C/ C9orf55 monoclonal antibody

Anti-DEN4C/ DENND4C/ C9orf55 antibody for FACS & in-vivo assay

Target products collectionGo to DENND4C/DENND4C products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0356-Ab-1/ GM-Tg-hg-MP0356-Ab-2Anti-Human DENND4C monoclonal antibodyHuman
GM-Tg-rg-MP0356-Ab-1/ GM-Tg-rg-MP0356-Ab-2Anti-Rat DENND4C monoclonal antibodyRat
GM-Tg-mg-MP0356-Ab-1/ GM-Tg-mg-MP0356-Ab-2Anti-Mouse DENND4C monoclonal antibodyMouse
GM-Tg-cynog-MP0356-Ab-1/ GM-Tg-cynog-MP0356-Ab-2Anti-Cynomolgus/ Rhesus macaque DENND4C monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0356-Ab-1/ GM-Tg-felg-MP0356-Ab-2Anti-Feline DENND4C monoclonal antibodyFeline
GM-Tg-cang-MP0356-Ab-1/ GM-Tg-cang-MP0356-Ab-2Anti-Canine DENND4C monoclonal antibodyCanine
GM-Tg-bovg-MP0356-Ab-1/ GM-Tg-bovg-MP0356-Ab-2Anti-Bovine DENND4C monoclonal antibodyBovine
GM-Tg-equg-MP0356-Ab-1/ GM-Tg-equg-MP0356-Ab-2Anti-Equine DENND4C monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0356-Ab-1/ GM-Tg-hg-MP0356-Ab-2; GM-Tg-rg-MP0356-Ab-1/ GM-Tg-rg-MP0356-Ab-2;
GM-Tg-mg-MP0356-Ab-1/ GM-Tg-mg-MP0356-Ab-2; GM-Tg-cynog-MP0356-Ab-1/ GM-Tg-cynog-MP0356-Ab-2;
GM-Tg-felg-MP0356-Ab-1/ GM-Tg-felg-MP0356-Ab-2; GM-Tg-cang-MP0356-Ab-1/ GM-Tg-cang-MP0356-Ab-2;
GM-Tg-bovg-MP0356-Ab-1/ GM-Tg-bovg-MP0356-Ab-2; GM-Tg-equg-MP0356-Ab-1/ GM-Tg-equg-MP0356-Ab-2
Products NameAnti-DENND4C monoclonal antibody
Formatmab
Target NameDENND4C
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-DENND4C benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species DEN4C/ DENND4C/ C9orf55 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0356
    Target NameDENND4C
    Gene ID55667,329877,313340,712447,100856373,101098094,536760,100052312
    Gene Symbol and Synonyms1700065A05Rik,bA513M16.3,C9orf55,C9orf55B,DENND4C,RAB10GEF,RGD1308489
    Uniprot AccessionQ5VZ89
    Uniprot Entry NameDEN4C_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000137145
    Target ClassificationN/A

    The target: DENND4C, gene name: DENND4C, also named as C9orf55, C9orf55B, RAB10GEF, bA513M16.3. Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in cellular response to insulin stimulus; protein localization to plasma membrane; and regulation of Rab protein signal transduction. Located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.