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Anti-DMPK/ DM/ DM1 monoclonal antibody
Anti-DMPK/ DM/ DM1 antibody for FACS & in-vivo assay
Go to DMPK/DMPK products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0363-Ab-1/ GM-Tg-hg-MP0363-Ab-2 | Anti-Human DMPK monoclonal antibody | Human |
| GM-Tg-rg-MP0363-Ab-1/ GM-Tg-rg-MP0363-Ab-2 | Anti-Rat DMPK monoclonal antibody | Rat |
| GM-Tg-mg-MP0363-Ab-1/ GM-Tg-mg-MP0363-Ab-2 | Anti-Mouse DMPK monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0363-Ab-1/ GM-Tg-cynog-MP0363-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DMPK monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0363-Ab-1/ GM-Tg-felg-MP0363-Ab-2 | Anti-Feline DMPK monoclonal antibody | Feline |
| GM-Tg-cang-MP0363-Ab-1/ GM-Tg-cang-MP0363-Ab-2 | Anti-Canine DMPK monoclonal antibody | Canine |
| GM-Tg-bovg-MP0363-Ab-1/ GM-Tg-bovg-MP0363-Ab-2 | Anti-Bovine DMPK monoclonal antibody | Bovine |
| GM-Tg-equg-MP0363-Ab-1/ GM-Tg-equg-MP0363-Ab-2 | Anti-Equine DMPK monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0363-Ab-1/ GM-Tg-hg-MP0363-Ab-2; GM-Tg-rg-MP0363-Ab-1/ GM-Tg-rg-MP0363-Ab-2; GM-Tg-mg-MP0363-Ab-1/ GM-Tg-mg-MP0363-Ab-2; GM-Tg-cynog-MP0363-Ab-1/ GM-Tg-cynog-MP0363-Ab-2; GM-Tg-felg-MP0363-Ab-1/ GM-Tg-felg-MP0363-Ab-2; GM-Tg-cang-MP0363-Ab-1/ GM-Tg-cang-MP0363-Ab-2; GM-Tg-bovg-MP0363-Ab-1/ GM-Tg-bovg-MP0363-Ab-2; GM-Tg-equg-MP0363-Ab-1/ GM-Tg-equg-MP0363-Ab-2 |
| Products Name | Anti-DMPK monoclonal antibody |
| Format | mab |
| Target Name | DMPK |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-DMPK benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species DMPK/ DM/ DM1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm004213 | mouse Dmpk Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004213 | mouse Dmpk Lentivirus particle |
Target information
| Target ID | GM-MP0363 |
| Target Name | DMPK |
| Gene ID | 1760,13400,308405,715328,484436,101081940,513675,100146609 |
| Gene Symbol and Synonyms | DM,DM1,Dm15,DM1PK,DMK,DMPK,MDPK,MT-PK |
| Uniprot Accession | Q09013 |
| Uniprot Entry Name | DMPK_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Prostate Cancer |
| Gene Ensembl | ENSG00000104936 |
| Target Classification | Kinase |
The target: DMPK, gene name: DMPK, also named as DM, DM1, DM1PK, DMK, MDPK, MT-PK. The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-38 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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