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Anti-DSC1/ CDHF1/ DG2/DG3 monoclonal antibody
Anti-DSC1/ CDHF1/ DG2/DG3 antibody for FACS & in-vivo assay
Go to DSC1/DSC1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0373-Ab-1/ GM-Tg-hg-MP0373-Ab-2 | Anti-Human DSC1 monoclonal antibody | Human |
| GM-Tg-rg-MP0373-Ab-1/ GM-Tg-rg-MP0373-Ab-2 | Anti-Rat DSC1 monoclonal antibody | Rat |
| GM-Tg-mg-MP0373-Ab-1/ GM-Tg-mg-MP0373-Ab-2 | Anti-Mouse DSC1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0373-Ab-1/ GM-Tg-cynog-MP0373-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DSC1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0373-Ab-1/ GM-Tg-felg-MP0373-Ab-2 | Anti-Feline DSC1 monoclonal antibody | Feline |
| GM-Tg-cang-MP0373-Ab-1/ GM-Tg-cang-MP0373-Ab-2 | Anti-Canine DSC1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0373-Ab-1/ GM-Tg-bovg-MP0373-Ab-2 | Anti-Bovine DSC1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0373-Ab-1/ GM-Tg-equg-MP0373-Ab-2 | Anti-Equine DSC1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0373-Ab-1/ GM-Tg-hg-MP0373-Ab-2; GM-Tg-rg-MP0373-Ab-1/ GM-Tg-rg-MP0373-Ab-2; GM-Tg-mg-MP0373-Ab-1/ GM-Tg-mg-MP0373-Ab-2; GM-Tg-cynog-MP0373-Ab-1/ GM-Tg-cynog-MP0373-Ab-2; GM-Tg-felg-MP0373-Ab-1/ GM-Tg-felg-MP0373-Ab-2; GM-Tg-cang-MP0373-Ab-1/ GM-Tg-cang-MP0373-Ab-2; GM-Tg-bovg-MP0373-Ab-1/ GM-Tg-bovg-MP0373-Ab-2; GM-Tg-equg-MP0373-Ab-1/ GM-Tg-equg-MP0373-Ab-2 |
| Products Name | Anti-DSC1 monoclonal antibody |
| Format | mab |
| Target Name | DSC1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-DSC1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species DSC1/ CDHF1/ DG2/DG3 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0373 |
| Target Name | DSC1 |
| Gene ID | 1823,13505,291759,705332,490501,101083463,281127,100065884 |
| Gene Symbol and Synonyms | 1110020A10Rik,CDHF1,DG2/DG3,DG2DG3,dg3,DSC1,DSC1b |
| Uniprot Accession | Q08554,Q01107 |
| Uniprot Entry Name | DSC1_HUMAN,DSC1_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000134765 |
| Target Classification | N/A |
The target: DSC1, gene name: DSC1, also named as CDHF1, DG2/DG3. The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein. [provided by RefSeq, Nov 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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