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Anti-DSC2/ ARVD11/ CDHF2 monoclonal antibody
Anti-DSC2/ ARVD11/ CDHF2 antibody for FACS & in-vivo assay
Go to DSC2/DSC2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0374-Ab-1/ GM-Tg-hg-MP0374-Ab-2 | Anti-Human DSC2 monoclonal antibody | Human |
| GM-Tg-rg-MP0374-Ab-1/ GM-Tg-rg-MP0374-Ab-2 | Anti-Rat DSC2 monoclonal antibody | Rat |
| GM-Tg-mg-MP0374-Ab-1/ GM-Tg-mg-MP0374-Ab-2 | Anti-Mouse DSC2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0374-Ab-1/ GM-Tg-cynog-MP0374-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DSC2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0374-Ab-1/ GM-Tg-felg-MP0374-Ab-2 | Anti-Feline DSC2 monoclonal antibody | Feline |
| GM-Tg-cang-MP0374-Ab-1/ GM-Tg-cang-MP0374-Ab-2 | Anti-Canine DSC2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0374-Ab-1/ GM-Tg-bovg-MP0374-Ab-2 | Anti-Bovine DSC2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0374-Ab-1/ GM-Tg-equg-MP0374-Ab-2 | Anti-Equine DSC2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0374-Ab-1/ GM-Tg-hg-MP0374-Ab-2; GM-Tg-rg-MP0374-Ab-1/ GM-Tg-rg-MP0374-Ab-2; GM-Tg-mg-MP0374-Ab-1/ GM-Tg-mg-MP0374-Ab-2; GM-Tg-cynog-MP0374-Ab-1/ GM-Tg-cynog-MP0374-Ab-2; GM-Tg-felg-MP0374-Ab-1/ GM-Tg-felg-MP0374-Ab-2; GM-Tg-cang-MP0374-Ab-1/ GM-Tg-cang-MP0374-Ab-2; GM-Tg-bovg-MP0374-Ab-1/ GM-Tg-bovg-MP0374-Ab-2; GM-Tg-equg-MP0374-Ab-1/ GM-Tg-equg-MP0374-Ab-2 |
| Products Name | Anti-DSC2 monoclonal antibody |
| Format | mab |
| Target Name | DSC2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-DSC2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species DSC2/ ARVD11/ CDHF2 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP001632 | human DSC2 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001632 | human DSC2 Lentivirus particle |
Target information
| Target ID | GM-MP0374 |
| Target Name | DSC2 |
| Gene ID | 1824,13506,712942,403860,101085157,281128,100065829 |
| Gene Symbol and Synonyms | ARVD11,CDHF2,DG2,DGII/III,DSC2,DSC3 |
| Uniprot Accession | Q02487,P33545 |
| Uniprot Entry Name | DSC2_HUMAN,DSC2_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Ovary Cancer |
| Gene Ensembl | ENSG00000134755 |
| Target Classification | N/A |
The target: DSC2, gene name: DSC2, also named as ARVD11, CDHF2, DG2, DGII/III, DSC3. This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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