Anti-DSC3/ CDHF3/ DSC monoclonal antibody

Anti-DSC3/ CDHF3/ DSC antibody for FACS & in-vivo assay

Target products collectionGo to DSC3/DSC3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0375-Ab-1/ GM-Tg-hg-MP0375-Ab-2Anti-Human DSC3 monoclonal antibodyHuman
GM-Tg-rg-MP0375-Ab-1/ GM-Tg-rg-MP0375-Ab-2Anti-Rat DSC3 monoclonal antibodyRat
GM-Tg-mg-MP0375-Ab-1/ GM-Tg-mg-MP0375-Ab-2Anti-Mouse DSC3 monoclonal antibodyMouse
GM-Tg-cynog-MP0375-Ab-1/ GM-Tg-cynog-MP0375-Ab-2Anti-Cynomolgus/ Rhesus macaque DSC3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0375-Ab-1/ GM-Tg-felg-MP0375-Ab-2Anti-Feline DSC3 monoclonal antibodyFeline
GM-Tg-cang-MP0375-Ab-1/ GM-Tg-cang-MP0375-Ab-2Anti-Canine DSC3 monoclonal antibodyCanine
GM-Tg-bovg-MP0375-Ab-1/ GM-Tg-bovg-MP0375-Ab-2Anti-Bovine DSC3 monoclonal antibodyBovine
GM-Tg-equg-MP0375-Ab-1/ GM-Tg-equg-MP0375-Ab-2Anti-Equine DSC3 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0375-Ab-1/ GM-Tg-hg-MP0375-Ab-2; GM-Tg-rg-MP0375-Ab-1/ GM-Tg-rg-MP0375-Ab-2;
GM-Tg-mg-MP0375-Ab-1/ GM-Tg-mg-MP0375-Ab-2; GM-Tg-cynog-MP0375-Ab-1/ GM-Tg-cynog-MP0375-Ab-2;
GM-Tg-felg-MP0375-Ab-1/ GM-Tg-felg-MP0375-Ab-2; GM-Tg-cang-MP0375-Ab-1/ GM-Tg-cang-MP0375-Ab-2;
GM-Tg-bovg-MP0375-Ab-1/ GM-Tg-bovg-MP0375-Ab-2; GM-Tg-equg-MP0375-Ab-1/ GM-Tg-equg-MP0375-Ab-2
Products NameAnti-DSC3 monoclonal antibody
Formatmab
Target NameDSC3
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-DSC3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species DSC3/ CDHF3/ DSC VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0375
    Target NameDSC3
    Gene ID1825,13507,307563,712805,100685374,101084909,281129,100065754
    Gene Symbol and Synonyms5430426I24Rik,CDHF3,DSC,DSC1,DSC2,DSC3,DSC4,HT-CP
    Uniprot AccessionQ14574,Q28060
    Uniprot Entry NameDSC3_HUMAN,DSC3_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000134762
    Target ClassificationN/A

    The target: DSC3, gene name: DSC3, also named as CDHF3, DSC, DSC1, DSC2, DSC4, HT-CP. The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.