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Anti-DSC3/ CDHF3/ DSC monoclonal antibody
Anti-DSC3/ CDHF3/ DSC antibody for FACS & in-vivo assay
Go to DSC3/DSC3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0375-Ab-1/ GM-Tg-hg-MP0375-Ab-2 | Anti-Human DSC3 monoclonal antibody | Human |
| GM-Tg-rg-MP0375-Ab-1/ GM-Tg-rg-MP0375-Ab-2 | Anti-Rat DSC3 monoclonal antibody | Rat |
| GM-Tg-mg-MP0375-Ab-1/ GM-Tg-mg-MP0375-Ab-2 | Anti-Mouse DSC3 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0375-Ab-1/ GM-Tg-cynog-MP0375-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DSC3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0375-Ab-1/ GM-Tg-felg-MP0375-Ab-2 | Anti-Feline DSC3 monoclonal antibody | Feline |
| GM-Tg-cang-MP0375-Ab-1/ GM-Tg-cang-MP0375-Ab-2 | Anti-Canine DSC3 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0375-Ab-1/ GM-Tg-bovg-MP0375-Ab-2 | Anti-Bovine DSC3 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0375-Ab-1/ GM-Tg-equg-MP0375-Ab-2 | Anti-Equine DSC3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0375-Ab-1/ GM-Tg-hg-MP0375-Ab-2; GM-Tg-rg-MP0375-Ab-1/ GM-Tg-rg-MP0375-Ab-2; GM-Tg-mg-MP0375-Ab-1/ GM-Tg-mg-MP0375-Ab-2; GM-Tg-cynog-MP0375-Ab-1/ GM-Tg-cynog-MP0375-Ab-2; GM-Tg-felg-MP0375-Ab-1/ GM-Tg-felg-MP0375-Ab-2; GM-Tg-cang-MP0375-Ab-1/ GM-Tg-cang-MP0375-Ab-2; GM-Tg-bovg-MP0375-Ab-1/ GM-Tg-bovg-MP0375-Ab-2; GM-Tg-equg-MP0375-Ab-1/ GM-Tg-equg-MP0375-Ab-2 |
| Products Name | Anti-DSC3 monoclonal antibody |
| Format | mab |
| Target Name | DSC3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-DSC3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species DSC3/ CDHF3/ DSC VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0375 |
| Target Name | DSC3 |
| Gene ID | 1825,13507,307563,712805,100685374,101084909,281129,100065754 |
| Gene Symbol and Synonyms | 5430426I24Rik,CDHF3,DSC,DSC1,DSC2,DSC3,DSC4,HT-CP |
| Uniprot Accession | Q14574,Q28060 |
| Uniprot Entry Name | DSC3_HUMAN,DSC3_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000134762 |
| Target Classification | N/A |
The target: DSC3, gene name: DSC3, also named as CDHF3, DSC, DSC1, DSC2, DSC4, HT-CP. The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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