Anti-DSG4/ CDGF13/ CDHF13 monoclonal antibody

Anti-DSG4/ CDGF13/ CDHF13 antibody for FACS & in-vivo assay

Target products collectionGo to DSG4/DSG4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0380-Ab-1/ GM-Tg-hg-MP0380-Ab-2Anti-Human DSG4 monoclonal antibodyHuman
GM-Tg-rg-MP0380-Ab-1/ GM-Tg-rg-MP0380-Ab-2Anti-Rat DSG4 monoclonal antibodyRat
GM-Tg-mg-MP0380-Ab-1/ GM-Tg-mg-MP0380-Ab-2Anti-Mouse DSG4 monoclonal antibodyMouse
GM-Tg-cynog-MP0380-Ab-1/ GM-Tg-cynog-MP0380-Ab-2Anti-Cynomolgus/ Rhesus macaque DSG4 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0380-Ab-1/ GM-Tg-felg-MP0380-Ab-2Anti-Feline DSG4 monoclonal antibodyFeline
GM-Tg-cang-MP0380-Ab-1/ GM-Tg-cang-MP0380-Ab-2Anti-Canine DSG4 monoclonal antibodyCanine
GM-Tg-bovg-MP0380-Ab-1/ GM-Tg-bovg-MP0380-Ab-2Anti-Bovine DSG4 monoclonal antibodyBovine
GM-Tg-equg-MP0380-Ab-1/ GM-Tg-equg-MP0380-Ab-2Anti-Equine DSG4 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0380-Ab-1/ GM-Tg-hg-MP0380-Ab-2; GM-Tg-rg-MP0380-Ab-1/ GM-Tg-rg-MP0380-Ab-2;
GM-Tg-mg-MP0380-Ab-1/ GM-Tg-mg-MP0380-Ab-2; GM-Tg-cynog-MP0380-Ab-1/ GM-Tg-cynog-MP0380-Ab-2;
GM-Tg-felg-MP0380-Ab-1/ GM-Tg-felg-MP0380-Ab-2; GM-Tg-cang-MP0380-Ab-1/ GM-Tg-cang-MP0380-Ab-2;
GM-Tg-bovg-MP0380-Ab-1/ GM-Tg-bovg-MP0380-Ab-2; GM-Tg-equg-MP0380-Ab-1/ GM-Tg-equg-MP0380-Ab-2
Products NameAnti-DSG4 monoclonal antibody
Formatmab
Target NameDSG4
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-DSG4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species DSG4/ CDGF13/ CDHF13 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0380
    Target NameDSG4
    Gene ID147409,16769,291754,713015,612592,101085667,537755,100065957
    Gene Symbol and SynonymsCDGF13,CDHF13,DSG4,HYPT6,LAH
    Uniprot AccessionQ86SJ6,Q6W3B0
    Uniprot Entry NameDSG4_HUMAN,DSG4_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000175065
    Target ClassificationN/A

    The target: DSG4, gene name: DSG4, also named as CDGF13, CDHF13, HYPT6, LAH. This gene encodes a member of the desmoglein subgroup of desmosomal cadherins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a transmembrane component of desmosomes and may play a role in cell-cell adhesion in epithelial cells. Mutations in the gene are associated with localized autosomal recessive hypotrichosis and monilethrix, characterized by impaired hair growth. [provided by RefSeq, May 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.