- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-DUOX2/ LNOX2/ NOXEF2 monoclonal antibody
Anti-DUOX2/ LNOX2/ NOXEF2 antibody for FACS & in-vivo assay
Go to DUOX2/DUOX2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0383-Ab-1/ GM-Tg-hg-MP0383-Ab-2 | Anti-Human DUOX2 monoclonal antibody | Human |
| GM-Tg-rg-MP0383-Ab-1/ GM-Tg-rg-MP0383-Ab-2 | Anti-Rat DUOX2 monoclonal antibody | Rat |
| GM-Tg-mg-MP0383-Ab-1/ GM-Tg-mg-MP0383-Ab-2 | Anti-Mouse DUOX2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0383-Ab-1/ GM-Tg-cynog-MP0383-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DUOX2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0383-Ab-1/ GM-Tg-felg-MP0383-Ab-2 | Anti-Feline DUOX2 monoclonal antibody | Feline |
| GM-Tg-cang-MP0383-Ab-1/ GM-Tg-cang-MP0383-Ab-2 | Anti-Canine DUOX2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0383-Ab-1/ GM-Tg-bovg-MP0383-Ab-2 | Anti-Bovine DUOX2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0383-Ab-1/ GM-Tg-equg-MP0383-Ab-2 | Anti-Equine DUOX2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0383-Ab-1/ GM-Tg-hg-MP0383-Ab-2; GM-Tg-rg-MP0383-Ab-1/ GM-Tg-rg-MP0383-Ab-2; GM-Tg-mg-MP0383-Ab-1/ GM-Tg-mg-MP0383-Ab-2; GM-Tg-cynog-MP0383-Ab-1/ GM-Tg-cynog-MP0383-Ab-2; GM-Tg-felg-MP0383-Ab-1/ GM-Tg-felg-MP0383-Ab-2; GM-Tg-cang-MP0383-Ab-1/ GM-Tg-cang-MP0383-Ab-2; GM-Tg-bovg-MP0383-Ab-1/ GM-Tg-bovg-MP0383-Ab-2; GM-Tg-equg-MP0383-Ab-1/ GM-Tg-equg-MP0383-Ab-2 |
| Products Name | Anti-DUOX2 monoclonal antibody |
| Format | mab |
| Target Name | DUOX2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-DUOX2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species DUOX2/ LNOX2/ NOXEF2 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0383 |
| Target Name | DUOX2 |
| Gene ID | 50506,214593,79107,713906,403719,101087408,785698,100070566 |
| Gene Symbol and Synonyms | A430065P05Rik,DUOX2,LNOX2,NOXEF2,P138-TOX,TDH6,THOX2 |
| Uniprot Accession | Q9NRD8,Q9ES45 |
| Uniprot Entry Name | DUOX2_HUMAN,DUOX2_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000140279 |
| Target Classification | N/A |
The target: DUOX2, gene name: DUOX2, also named as LNOX2, NOXEF2, P138-TOX, TDH6, THOX2. The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
