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Anti-DOXA2/ DUOXA2/ SIMNIPHOM monoclonal antibody
Anti-DOXA2/ DUOXA2/ SIMNIPHOM antibody for FACS & in-vivo assay
Go to DUOXA2/DUOXA2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0385-Ab-1/ GM-Tg-hg-MP0385-Ab-2 | Anti-Human DUOXA2 monoclonal antibody | Human |
| GM-Tg-rg-MP0385-Ab-1/ GM-Tg-rg-MP0385-Ab-2 | Anti-Rat DUOXA2 monoclonal antibody | Rat |
| GM-Tg-mg-MP0385-Ab-1/ GM-Tg-mg-MP0385-Ab-2 | Anti-Mouse DUOXA2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0385-Ab-1/ GM-Tg-cynog-MP0385-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DUOXA2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0385-Ab-1/ GM-Tg-felg-MP0385-Ab-2 | Anti-Feline DUOXA2 monoclonal antibody | Feline |
| GM-Tg-cang-MP0385-Ab-1/ GM-Tg-cang-MP0385-Ab-2 | Anti-Canine DUOXA2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0385-Ab-1/ GM-Tg-bovg-MP0385-Ab-2 | Anti-Bovine DUOXA2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0385-Ab-1/ GM-Tg-equg-MP0385-Ab-2 | Anti-Equine DUOXA2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0385-Ab-1/ GM-Tg-hg-MP0385-Ab-2; GM-Tg-rg-MP0385-Ab-1/ GM-Tg-rg-MP0385-Ab-2; GM-Tg-mg-MP0385-Ab-1/ GM-Tg-mg-MP0385-Ab-2; GM-Tg-cynog-MP0385-Ab-1/ GM-Tg-cynog-MP0385-Ab-2; GM-Tg-felg-MP0385-Ab-1/ GM-Tg-felg-MP0385-Ab-2; GM-Tg-cang-MP0385-Ab-1/ GM-Tg-cang-MP0385-Ab-2; GM-Tg-bovg-MP0385-Ab-1/ GM-Tg-bovg-MP0385-Ab-2; GM-Tg-equg-MP0385-Ab-1/ GM-Tg-equg-MP0385-Ab-2 |
| Products Name | Anti-DUOXA2 monoclonal antibody |
| Format | mab |
| Target Name | DUOXA2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-DUOXA2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species DOXA2/ DUOXA2/ SIMNIPHOM VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP004958 | human Duoxa2 Lentivirus particle |
| ORF Viral Vector | pGMLP004958 | human Duoxa2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000516 | mouse Duoxa2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000516 | mouse Duoxa2 Lentivirus particle |
Target information
| Target ID | GM-MP0385 |
| Target Name | DUOXA2 |
| Gene ID | 405753,66811,499879,712992,100856790,101091628,514414,100070557 |
| Gene Symbol and Synonyms | 9030623N16Rik,DUOXA2,Nip2,RGD1560628,SIMNIPHOM,TDH5 |
| Uniprot Accession | Q1HG44 |
| Uniprot Entry Name | DOXA2_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000140274 |
| Target Classification | N/A |
The target: DUOXA2, gene name: DUOXA2, also named as SIMNIPHOM, TDH5. This gene encodes an endoplasmic reticulum protein that is necessary for proper cellular localization and maturation of functional dual oxidase 2. Mutations in this gene have been associated with thyroid dyshormonogenesis 5.[provided by RefSeq, Feb 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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