Anti-TNR27/ EDA2R/ EDA-A2R monoclonal antibody

Anti-TNR27/ EDA2R/ EDA-A2R antibody for FACS & in-vivo assay

Target products collectionGo to EDA2R/EDA2R products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0390-Ab-1/ GM-Tg-hg-MP0390-Ab-2Anti-Human EDA2R monoclonal antibodyHuman
GM-Tg-rg-MP0390-Ab-1/ GM-Tg-rg-MP0390-Ab-2Anti-Rat EDA2R monoclonal antibodyRat
GM-Tg-mg-MP0390-Ab-1/ GM-Tg-mg-MP0390-Ab-2Anti-Mouse EDA2R monoclonal antibodyMouse
GM-Tg-cynog-MP0390-Ab-1/ GM-Tg-cynog-MP0390-Ab-2Anti-Cynomolgus/ Rhesus macaque EDA2R monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0390-Ab-1/ GM-Tg-felg-MP0390-Ab-2Anti-Feline EDA2R monoclonal antibodyFeline
GM-Tg-cang-MP0390-Ab-1/ GM-Tg-cang-MP0390-Ab-2Anti-Canine EDA2R monoclonal antibodyCanine
GM-Tg-bovg-MP0390-Ab-1/ GM-Tg-bovg-MP0390-Ab-2Anti-Bovine EDA2R monoclonal antibodyBovine
GM-Tg-equg-MP0390-Ab-1/ GM-Tg-equg-MP0390-Ab-2Anti-Equine EDA2R monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0390-Ab-1/ GM-Tg-hg-MP0390-Ab-2; GM-Tg-rg-MP0390-Ab-1/ GM-Tg-rg-MP0390-Ab-2;
GM-Tg-mg-MP0390-Ab-1/ GM-Tg-mg-MP0390-Ab-2; GM-Tg-cynog-MP0390-Ab-1/ GM-Tg-cynog-MP0390-Ab-2;
GM-Tg-felg-MP0390-Ab-1/ GM-Tg-felg-MP0390-Ab-2; GM-Tg-cang-MP0390-Ab-1/ GM-Tg-cang-MP0390-Ab-2;
GM-Tg-bovg-MP0390-Ab-1/ GM-Tg-bovg-MP0390-Ab-2; GM-Tg-equg-MP0390-Ab-1/ GM-Tg-equg-MP0390-Ab-2
Products NameAnti-EDA2R monoclonal antibody
Formatmab
Target NameEDA2R
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-EDA2R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species TNR27/ EDA2R/ EDA-A2R VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0390
    Target NameEDA2R
    Gene ID60401,245527,296872,710244,101084857,100301324,100065857
    Gene Symbol and Synonyms9430060M22Rik,EDA-A2R,EDA2R,EDAA2R,RGD1564025,TNFRSF27,XEDAR
    Uniprot AccessionQ9HAV5
    Uniprot Entry NameTNR27_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000131080
    Target ClassificationN/A

    The target: EDA2R, gene name: EDA2R, also named as EDA-A2R, EDAA2R, TNFRSF27, XEDAR. The protein encoded by this gene is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains cysteine-rich repeats and a single transmembrane domain. This protein binds to the EDA-A2 isoform of ectodysplasin, which plays an important role in maintenance of hair and teeth. Alternatively spliced transcript variants encodes distinct protein isoforms. [provided by RefSeq, Apr 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.