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Anti-ENPP1/ ARHR2/ COLED monoclonal antibody
Anti-ENPP1/ ARHR2/ COLED antibody for FACS & in-vivo assay
Go to ENPP1/ENPP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0409-Ab-1/ GM-Tg-hg-MP0409-Ab-2 | Anti-Human ENPP1 monoclonal antibody | Human |
| GM-Tg-rg-MP0409-Ab-1/ GM-Tg-rg-MP0409-Ab-2 | Anti-Rat ENPP1 monoclonal antibody | Rat |
| GM-Tg-mg-MP0409-Ab-1/ GM-Tg-mg-MP0409-Ab-2 | Anti-Mouse ENPP1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0409-Ab-1/ GM-Tg-cynog-MP0409-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ENPP1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0409-Ab-1/ GM-Tg-felg-MP0409-Ab-2 | Anti-Feline ENPP1 monoclonal antibody | Feline |
| GM-Tg-cang-MP0409-Ab-1/ GM-Tg-cang-MP0409-Ab-2 | Anti-Canine ENPP1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0409-Ab-1/ GM-Tg-bovg-MP0409-Ab-2 | Anti-Bovine ENPP1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0409-Ab-1/ GM-Tg-equg-MP0409-Ab-2 | Anti-Equine ENPP1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0409-Ab-1/ GM-Tg-hg-MP0409-Ab-2; GM-Tg-rg-MP0409-Ab-1/ GM-Tg-rg-MP0409-Ab-2; GM-Tg-mg-MP0409-Ab-1/ GM-Tg-mg-MP0409-Ab-2; GM-Tg-cynog-MP0409-Ab-1/ GM-Tg-cynog-MP0409-Ab-2; GM-Tg-felg-MP0409-Ab-1/ GM-Tg-felg-MP0409-Ab-2; GM-Tg-cang-MP0409-Ab-1/ GM-Tg-cang-MP0409-Ab-2; GM-Tg-bovg-MP0409-Ab-1/ GM-Tg-bovg-MP0409-Ab-2; GM-Tg-equg-MP0409-Ab-1/ GM-Tg-equg-MP0409-Ab-2 |
| Products Name | Anti-ENPP1 monoclonal antibody |
| Format | mab |
| Target Name | ENPP1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ENPP1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ENPP1/ ARHR2/ COLED VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm004085 | mouse Enpp1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004085 | mouse Enpp1 Lentivirus particle |
Target information
| Target ID | GM-MP0409 |
| Target Name | ENPP1 |
| Gene ID | 5167,18605,85496,710140,100856150,101094350,615535,100073097 |
| Gene Symbol and Synonyms | 4833416E15Rik,ARHR2,CD203c,COLED,E-NPP 1,E-NPP1,ENPP1,Ly-41,M6S1,NPP1,NPPS,PC-1,Pc1,Pca,Pca-1,PCA1,PDNP1,ttw,twy |
| Uniprot Accession | P22413,Q924C3 |
| Uniprot Entry Name | ENPP1_HUMAN,ENPP1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000197594 |
| Target Classification | N/A |
The target: ENPP1, gene name: ENPP1, also named as ARHR2, COLED, M6S1, NPP1, NPPS, PC-1, PCA1, PDNP1. This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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