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Anti-SYCY1/ ERVW-1/ ENV monoclonal antibody
Anti-SYCY1/ ERVW-1/ ENV antibody for FACS & in-vivo assay
Go to ERVW-1/ERVW-1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0424-Ab-1/ GM-Tg-hg-MP0424-Ab-2 | Anti-Human ERVW-1 monoclonal antibody | Human |
| GM-Tg-rg-MP0424-Ab-1/ GM-Tg-rg-MP0424-Ab-2 | Anti-Rat ERVW-1 monoclonal antibody | Rat |
| GM-Tg-mg-MP0424-Ab-1/ GM-Tg-mg-MP0424-Ab-2 | Anti-Mouse ERVW-1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0424-Ab-1/ GM-Tg-cynog-MP0424-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ERVW-1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0424-Ab-1/ GM-Tg-felg-MP0424-Ab-2 | Anti-Feline ERVW-1 monoclonal antibody | Feline |
| GM-Tg-cang-MP0424-Ab-1/ GM-Tg-cang-MP0424-Ab-2 | Anti-Canine ERVW-1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0424-Ab-1/ GM-Tg-bovg-MP0424-Ab-2 | Anti-Bovine ERVW-1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0424-Ab-1/ GM-Tg-equg-MP0424-Ab-2 | Anti-Equine ERVW-1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0424-Ab-1/ GM-Tg-hg-MP0424-Ab-2; GM-Tg-rg-MP0424-Ab-1/ GM-Tg-rg-MP0424-Ab-2; GM-Tg-mg-MP0424-Ab-1/ GM-Tg-mg-MP0424-Ab-2; GM-Tg-cynog-MP0424-Ab-1/ GM-Tg-cynog-MP0424-Ab-2; GM-Tg-felg-MP0424-Ab-1/ GM-Tg-felg-MP0424-Ab-2; GM-Tg-cang-MP0424-Ab-1/ GM-Tg-cang-MP0424-Ab-2; GM-Tg-bovg-MP0424-Ab-1/ GM-Tg-bovg-MP0424-Ab-2; GM-Tg-equg-MP0424-Ab-1/ GM-Tg-equg-MP0424-Ab-2 |
| Products Name | Anti-ERVW-1 monoclonal antibody |
| Format | mab |
| Target Name | ERVW-1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ERVW-1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species SYCY1/ ERVW-1/ ENV VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0424 |
| Target Name | ERVW-1 |
| Gene ID | 30816,114676987 |
| Gene Symbol and Synonyms | ENV,ENVW,ERVW-1,ERVWE1,HERV-7q,HERV-W-ENV,HERV7Q,HERVW,HERVWENV |
| Uniprot Accession | Q9UQF0 |
| Uniprot Entry Name | SYCY1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000242950 |
| Target Classification | N/A |
The target: ERVW-1, gene name: ERVW-1, also named as ENV, ENVW, ERVWE1, HERV-7q, HERV-W-ENV, HERV7Q, HERVW, HERVWENV. Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (™) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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