Anti-FLVC2/ FLVCR2/ C14orf58 monoclonal antibody

Anti-FLVC2/ FLVCR2/ C14orf58 antibody for FACS & in-vivo assay

Target products collectionGo to FLVCR2/FLVCR2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0447-Ab-1/ GM-Tg-hg-MP0447-Ab-2Anti-Human FLVCR2 monoclonal antibodyHuman
GM-Tg-rg-MP0447-Ab-1/ GM-Tg-rg-MP0447-Ab-2Anti-Rat FLVCR2 monoclonal antibodyRat
GM-Tg-mg-MP0447-Ab-1/ GM-Tg-mg-MP0447-Ab-2Anti-Mouse FLVCR2 monoclonal antibodyMouse
GM-Tg-cynog-MP0447-Ab-1/ GM-Tg-cynog-MP0447-Ab-2Anti-Cynomolgus/ Rhesus macaque FLVCR2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0447-Ab-1/ GM-Tg-felg-MP0447-Ab-2Anti-Feline FLVCR2 monoclonal antibodyFeline
GM-Tg-cang-MP0447-Ab-1/ GM-Tg-cang-MP0447-Ab-2Anti-Canine FLVCR2 monoclonal antibodyCanine
GM-Tg-bovg-MP0447-Ab-1/ GM-Tg-bovg-MP0447-Ab-2Anti-Bovine FLVCR2 monoclonal antibodyBovine
GM-Tg-equg-MP0447-Ab-1/ GM-Tg-equg-MP0447-Ab-2Anti-Equine FLVCR2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0447-Ab-1/ GM-Tg-hg-MP0447-Ab-2; GM-Tg-rg-MP0447-Ab-1/ GM-Tg-rg-MP0447-Ab-2;
GM-Tg-mg-MP0447-Ab-1/ GM-Tg-mg-MP0447-Ab-2; GM-Tg-cynog-MP0447-Ab-1/ GM-Tg-cynog-MP0447-Ab-2;
GM-Tg-felg-MP0447-Ab-1/ GM-Tg-felg-MP0447-Ab-2; GM-Tg-cang-MP0447-Ab-1/ GM-Tg-cang-MP0447-Ab-2;
GM-Tg-bovg-MP0447-Ab-1/ GM-Tg-bovg-MP0447-Ab-2; GM-Tg-equg-MP0447-Ab-1/ GM-Tg-equg-MP0447-Ab-2
Products NameAnti-FLVCR2 monoclonal antibody
Formatmab
Target NameFLVCR2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-FLVCR2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species FLVC2/ FLVCR2/ C14orf58 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0447
    Target NameFLVCR2
    Gene ID55640,217721,314323,702759,490795,101084034
    Gene Symbol and SynonymsC14orf58,CCT,EPV,FLVCR2,FLVCRL14q,MFSD7C,PVHH,SLC49A2
    Uniprot AccessionQ9UPI3,P60815
    Uniprot Entry NameFLVC2_HUMAN,FLVC2_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000119686
    Target ClassificationN/A

    The target: FLVCR2, gene name: FLVCR2, also named as C14orf58, CCT, EPV, FLVCRL14q, MFSD7C, PVHH, SLC49A2. This gene encodes a member of the major facilitator superfamily. The encoded transmembrane protein is a calcium transporter. Unlike the related protein feline leukemia virus subgroup C receptor 1, the protein encoded by this locus does not bind to feline leukemia virus subgroup C envelope protein. The encoded protein may play a role in development of brain vascular endothelial cells, as mutations at this locus have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Aug 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.