Anti-JUNO/ IZUMO1R/ FOLR4 monoclonal antibody

Anti-JUNO/ IZUMO1R/ FOLR4 antibody for FACS & in-vivo assay

Target products collectionGo to IZUMO1R/IZUMO1R products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0450-Ab-1/ GM-Tg-hg-MP0450-Ab-2Anti-Human IZUMO1R monoclonal antibodyHuman
GM-Tg-rg-MP0450-Ab-1/ GM-Tg-rg-MP0450-Ab-2Anti-Rat IZUMO1R monoclonal antibodyRat
GM-Tg-mg-MP0450-Ab-1/ GM-Tg-mg-MP0450-Ab-2Anti-Mouse IZUMO1R monoclonal antibodyMouse
GM-Tg-cynog-MP0450-Ab-1/ GM-Tg-cynog-MP0450-Ab-2Anti-Cynomolgus/ Rhesus macaque IZUMO1R monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0450-Ab-1/ GM-Tg-felg-MP0450-Ab-2Anti-Feline IZUMO1R monoclonal antibodyFeline
GM-Tg-cang-MP0450-Ab-1/ GM-Tg-cang-MP0450-Ab-2Anti-Canine IZUMO1R monoclonal antibodyCanine
GM-Tg-bovg-MP0450-Ab-1/ GM-Tg-bovg-MP0450-Ab-2Anti-Bovine IZUMO1R monoclonal antibodyBovine
GM-Tg-equg-MP0450-Ab-1/ GM-Tg-equg-MP0450-Ab-2Anti-Equine IZUMO1R monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0450-Ab-1/ GM-Tg-hg-MP0450-Ab-2; GM-Tg-rg-MP0450-Ab-1/ GM-Tg-rg-MP0450-Ab-2;
GM-Tg-mg-MP0450-Ab-1/ GM-Tg-mg-MP0450-Ab-2; GM-Tg-cynog-MP0450-Ab-1/ GM-Tg-cynog-MP0450-Ab-2;
GM-Tg-felg-MP0450-Ab-1/ GM-Tg-felg-MP0450-Ab-2; GM-Tg-cang-MP0450-Ab-1/ GM-Tg-cang-MP0450-Ab-2;
GM-Tg-bovg-MP0450-Ab-1/ GM-Tg-bovg-MP0450-Ab-2; GM-Tg-equg-MP0450-Ab-1/ GM-Tg-equg-MP0450-Ab-2
Products NameAnti-IZUMO1R monoclonal antibody
Formatmab
Target NameIZUMO1R
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IZUMO1R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species JUNO/ IZUMO1R/ FOLR4 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0450
    Target NameIZUMO1R
    Gene ID390243,64931,690037,698653,607523,101087423,100300332,100058199
    Gene Symbol and Synonyms0910001L11Rik,Folbp3,FOLR4,FR-delta,IZUMO1R,JUNO
    Uniprot AccessionA6ND01
    Uniprot Entry NameJUNO_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000183560
    Target ClassificationN/A

    The target: IZUMO1R, gene name: IZUMO1R, also named as FOLR4, Folbp3, JUNO. Enables signaling receptor activity. Predicted to be involved in cell adhesion; fusion of sperm to egg plasma membrane involved in single fertilization; and sperm-egg recognition. Predicted to be located in extracellular region and plasma membrane. Predicted to be anchored component of external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.