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Anti-FXYD4/ CHIF monoclonal antibody
Anti-FXYD4/ CHIF antibody for FACS & in-vivo assay
Go to FXYD4/FXYD4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0457-Ab-1/ GM-Tg-hg-MP0457-Ab-2 | Anti-Human FXYD4 monoclonal antibody | Human |
| GM-Tg-rg-MP0457-Ab-1/ GM-Tg-rg-MP0457-Ab-2 | Anti-Rat FXYD4 monoclonal antibody | Rat |
| GM-Tg-mg-MP0457-Ab-1/ GM-Tg-mg-MP0457-Ab-2 | Anti-Mouse FXYD4 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0457-Ab-1/ GM-Tg-cynog-MP0457-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FXYD4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0457-Ab-1/ GM-Tg-felg-MP0457-Ab-2 | Anti-Feline FXYD4 monoclonal antibody | Feline |
| GM-Tg-cang-MP0457-Ab-1/ GM-Tg-cang-MP0457-Ab-2 | Anti-Canine FXYD4 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0457-Ab-1/ GM-Tg-bovg-MP0457-Ab-2 | Anti-Bovine FXYD4 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0457-Ab-1/ GM-Tg-equg-MP0457-Ab-2 | Anti-Equine FXYD4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0457-Ab-1/ GM-Tg-hg-MP0457-Ab-2; GM-Tg-rg-MP0457-Ab-1/ GM-Tg-rg-MP0457-Ab-2; GM-Tg-mg-MP0457-Ab-1/ GM-Tg-mg-MP0457-Ab-2; GM-Tg-cynog-MP0457-Ab-1/ GM-Tg-cynog-MP0457-Ab-2; GM-Tg-felg-MP0457-Ab-1/ GM-Tg-felg-MP0457-Ab-2; GM-Tg-cang-MP0457-Ab-1/ GM-Tg-cang-MP0457-Ab-2; GM-Tg-bovg-MP0457-Ab-1/ GM-Tg-bovg-MP0457-Ab-2; GM-Tg-equg-MP0457-Ab-1/ GM-Tg-equg-MP0457-Ab-2 |
| Products Name | Anti-FXYD4 monoclonal antibody |
| Format | mab |
| Target Name | FXYD4 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-FXYD4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species FXYD4/ CHIF VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0457 |
| Target Name | FXYD4 |
| Gene ID | 53828,108017,64190,107000109,102156028,109492905,100295639,100629797 |
| Gene Symbol and Synonyms | 0610008I02Rik,CHIF,FXYD4 |
| Uniprot Accession | P59646,Q63113 |
| Uniprot Entry Name | FXYD4_HUMAN,FXYD4_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000150201 |
| Target Classification | N/A |
The target: FXYD4, gene name: FXYD4, also named as CHIF. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. FXYD4, originally named CHIF for channel-inducing factor, has been shown to modulate the properties of the Na,K-ATPase, as has FXYD2, also known as the gamma subunit of the Na,K-ATPase, and FXYD7. Transmembrane topology has been established for FXYD4 and two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. Alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, May 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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