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Protocol Library Download
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Anti-FZD6/ FZ-6/ FZ6 monoclonal antibody
Anti-FZD6/ FZ-6/ FZ6 antibody for FACS & in-vivo assay
Go to FZD6/FZD6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0465-Ab-1/ GM-Tg-hg-MP0465-Ab-2 | Anti-Human FZD6 monoclonal antibody | Human |
| GM-Tg-rg-MP0465-Ab-1/ GM-Tg-rg-MP0465-Ab-2 | Anti-Rat FZD6 monoclonal antibody | Rat |
| GM-Tg-mg-MP0465-Ab-1/ GM-Tg-mg-MP0465-Ab-2 | Anti-Mouse FZD6 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0465-Ab-1/ GM-Tg-cynog-MP0465-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FZD6 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0465-Ab-1/ GM-Tg-felg-MP0465-Ab-2 | Anti-Feline FZD6 monoclonal antibody | Feline |
| GM-Tg-cang-MP0465-Ab-1/ GM-Tg-cang-MP0465-Ab-2 | Anti-Canine FZD6 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0465-Ab-1/ GM-Tg-bovg-MP0465-Ab-2 | Anti-Bovine FZD6 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0465-Ab-1/ GM-Tg-equg-MP0465-Ab-2 | Anti-Equine FZD6 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0465-Ab-1/ GM-Tg-hg-MP0465-Ab-2; GM-Tg-rg-MP0465-Ab-1/ GM-Tg-rg-MP0465-Ab-2; GM-Tg-mg-MP0465-Ab-1/ GM-Tg-mg-MP0465-Ab-2; GM-Tg-cynog-MP0465-Ab-1/ GM-Tg-cynog-MP0465-Ab-2; GM-Tg-felg-MP0465-Ab-1/ GM-Tg-felg-MP0465-Ab-2; GM-Tg-cang-MP0465-Ab-1/ GM-Tg-cang-MP0465-Ab-2; GM-Tg-bovg-MP0465-Ab-1/ GM-Tg-bovg-MP0465-Ab-2; GM-Tg-equg-MP0465-Ab-1/ GM-Tg-equg-MP0465-Ab-2 |
| Products Name | Anti-FZD6 monoclonal antibody |
| Format | mab |
| Target Name | FZD6 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-FZD6 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species FZD6/ FZ-6/ FZ6 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP0465-Ag-1 | frizzled class receptor 6 (FZD6) protein |
| ORF Viral Vector | vGMLP001182 | human FZD6 Lentivirus particle |
| ORF Viral Vector | pGMLP001182 | human FZD6 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm004035 | mouse Fzd6 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004035 | mouse Fzd6 Lentivirus particle |
Target information
| Target ID | GM-MP0465 |
| Target Name | FZD6 |
| Gene ID | 8323,14368,282581,694625,403610,101101443,445418,100056351 |
| Gene Symbol and Synonyms | Frizzled-6,FZ-6,FZ6,FZD6,HFZ6,NDNC1,NDNC10 |
| Uniprot Accession | O60353,Q8WMU5 |
| Uniprot Entry Name | FZD6_HUMAN,FZD6_CANLF |
| Protein Sub-location | Transmembrane Protein |
| Category | Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000164930 |
| Target Classification | N/A |
The target: FZD6, gene name: FZD6, also named as FZ-6, FZ6, HFZ6, NDNC10. This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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