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Anti-GBRA6/ GABRA6 monoclonal antibody
Anti-GBRA6/ GABRA6 antibody for FACS & in-vivo assay
Go to GABRA6/GABRA6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0469-Ab-1/ GM-Tg-hg-MP0469-Ab-2 | Anti-Human GABRA6 monoclonal antibody | Human |
| GM-Tg-rg-MP0469-Ab-1/ GM-Tg-rg-MP0469-Ab-2 | Anti-Rat GABRA6 monoclonal antibody | Rat |
| GM-Tg-mg-MP0469-Ab-1/ GM-Tg-mg-MP0469-Ab-2 | Anti-Mouse GABRA6 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0469-Ab-1/ GM-Tg-cynog-MP0469-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GABRA6 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0469-Ab-1/ GM-Tg-felg-MP0469-Ab-2 | Anti-Feline GABRA6 monoclonal antibody | Feline |
| GM-Tg-cang-MP0469-Ab-1/ GM-Tg-cang-MP0469-Ab-2 | Anti-Canine GABRA6 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0469-Ab-1/ GM-Tg-bovg-MP0469-Ab-2 | Anti-Bovine GABRA6 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0469-Ab-1/ GM-Tg-equg-MP0469-Ab-2 | Anti-Equine GABRA6 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0469-Ab-1/ GM-Tg-hg-MP0469-Ab-2; GM-Tg-rg-MP0469-Ab-1/ GM-Tg-rg-MP0469-Ab-2; GM-Tg-mg-MP0469-Ab-1/ GM-Tg-mg-MP0469-Ab-2; GM-Tg-cynog-MP0469-Ab-1/ GM-Tg-cynog-MP0469-Ab-2; GM-Tg-felg-MP0469-Ab-1/ GM-Tg-felg-MP0469-Ab-2; GM-Tg-cang-MP0469-Ab-1/ GM-Tg-cang-MP0469-Ab-2; GM-Tg-bovg-MP0469-Ab-1/ GM-Tg-bovg-MP0469-Ab-2; GM-Tg-equg-MP0469-Ab-1/ GM-Tg-equg-MP0469-Ab-2 |
| Products Name | Anti-GABRA6 monoclonal antibody |
| Format | mab |
| Target Name | GABRA6 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GABRA6 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species GBRA6/ GABRA6 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP003717 | human GABRA6 Lentivirus particle |
| ORF Viral Vector | pGMLP003717 | human GABRA6 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm005264 | mouse Gabra6 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005264 | mouse Gabra6 Lentivirus particle |
Target information
| Target ID | GM-MP0469 |
| Target Name | GABRA6 |
| Gene ID | 2559,14399,29708,697010,489145,101093992,539194,100070890 |
| Gene Symbol and Synonyms | alpha6,GABA-ARalpha6,Gabra-6,GABRA6 |
| Uniprot Accession | Q16445,P30191 |
| Uniprot Entry Name | GBRA6_HUMAN,GBRA6_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000145863 |
| Target Classification | Ion Channel |
The target: GABRA6, gene name: GABRA6, also named as . GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified..
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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