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Anti-GP2/ ZAP75 monoclonal antibody
Anti-GP2/ ZAP75 antibody for FACS & in-vivo assay
Go to GP2/GP2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0487-Ab-1/ GM-Tg-hg-MP0487-Ab-2 | Anti-Human GP2 monoclonal antibody | Human |
| GM-Tg-rg-MP0487-Ab-1/ GM-Tg-rg-MP0487-Ab-2 | Anti-Rat GP2 monoclonal antibody | Rat |
| GM-Tg-mg-MP0487-Ab-1/ GM-Tg-mg-MP0487-Ab-2 | Anti-Mouse GP2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0487-Ab-1/ GM-Tg-cynog-MP0487-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GP2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0487-Ab-1/ GM-Tg-felg-MP0487-Ab-2 | Anti-Feline GP2 monoclonal antibody | Feline |
| GM-Tg-cang-MP0487-Ab-1/ GM-Tg-cang-MP0487-Ab-2 | Anti-Canine GP2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0487-Ab-1/ GM-Tg-bovg-MP0487-Ab-2 | Anti-Bovine GP2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0487-Ab-1/ GM-Tg-equg-MP0487-Ab-2 | Anti-Equine GP2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0487-Ab-1/ GM-Tg-hg-MP0487-Ab-2; GM-Tg-rg-MP0487-Ab-1/ GM-Tg-rg-MP0487-Ab-2; GM-Tg-mg-MP0487-Ab-1/ GM-Tg-mg-MP0487-Ab-2; GM-Tg-cynog-MP0487-Ab-1/ GM-Tg-cynog-MP0487-Ab-2; GM-Tg-felg-MP0487-Ab-1/ GM-Tg-felg-MP0487-Ab-2; GM-Tg-cang-MP0487-Ab-1/ GM-Tg-cang-MP0487-Ab-2; GM-Tg-bovg-MP0487-Ab-1/ GM-Tg-bovg-MP0487-Ab-2; GM-Tg-equg-MP0487-Ab-1/ GM-Tg-equg-MP0487-Ab-2 |
| Products Name | Anti-GP2 monoclonal antibody |
| Format | mab |
| Target Name | GP2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GP2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species GP2/ ZAP75 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm002006 | mouse Gp2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002006 | mouse Gp2 Lentivirus particle |
Target information
| Target ID | GM-MP0487 |
| Target Name | GP2 |
| Gene ID | 2813,67133,171459,695766,442972,101084504,531420,100051807 |
| Gene Symbol and Synonyms | 2310037I18Rik,GP2,gp80,ZAP75 |
| Uniprot Accession | P55259,P19218,P25291 |
| Uniprot Entry Name | GP2_HUMAN,GP2_RAT,GP2_CANLF |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000169347 |
| Target Classification | N/A |
The target: GP2, gene name: GP2, also named as ZAP75. This gene encodes an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. The encoded protein binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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