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Anti-GP153/ GPR153/ PGR1 monoclonal antibody
Anti-GP153/ GPR153/ PGR1 antibody for FACS & in-vivo assay
Go to GPR153/GPR153 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0516-Ab-1/ GM-Tg-hg-MP0516-Ab-2 | Anti-Human GPR153 monoclonal antibody | Human |
| GM-Tg-rg-MP0516-Ab-1/ GM-Tg-rg-MP0516-Ab-2 | Anti-Rat GPR153 monoclonal antibody | Rat |
| GM-Tg-mg-MP0516-Ab-1/ GM-Tg-mg-MP0516-Ab-2 | Anti-Mouse GPR153 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0516-Ab-1/ GM-Tg-cynog-MP0516-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GPR153 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0516-Ab-1/ GM-Tg-felg-MP0516-Ab-2 | Anti-Feline GPR153 monoclonal antibody | Feline |
| GM-Tg-cang-MP0516-Ab-1/ GM-Tg-cang-MP0516-Ab-2 | Anti-Canine GPR153 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0516-Ab-1/ GM-Tg-bovg-MP0516-Ab-2 | Anti-Bovine GPR153 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0516-Ab-1/ GM-Tg-equg-MP0516-Ab-2 | Anti-Equine GPR153 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0516-Ab-1/ GM-Tg-hg-MP0516-Ab-2; GM-Tg-rg-MP0516-Ab-1/ GM-Tg-rg-MP0516-Ab-2; GM-Tg-mg-MP0516-Ab-1/ GM-Tg-mg-MP0516-Ab-2; GM-Tg-cynog-MP0516-Ab-1/ GM-Tg-cynog-MP0516-Ab-2; GM-Tg-felg-MP0516-Ab-1/ GM-Tg-felg-MP0516-Ab-2; GM-Tg-cang-MP0516-Ab-1/ GM-Tg-cang-MP0516-Ab-2; GM-Tg-bovg-MP0516-Ab-1/ GM-Tg-bovg-MP0516-Ab-2; GM-Tg-equg-MP0516-Ab-1/ GM-Tg-equg-MP0516-Ab-2 |
| Products Name | Anti-GPR153 monoclonal antibody |
| Format | mab |
| Target Name | GPR153 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GPR153 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species GP153/ GPR153/ PGR1 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0516 |
| Target Name | GPR153 |
| Gene ID | 387509,100129,619550,703169,489630,101093874,518906,100059643 |
| Gene Symbol and Synonyms | 1110065N12Rik,GPR153,PGR1 |
| Uniprot Accession | Q6NV75 |
| Uniprot Entry Name | GP153_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000158292 |
| Target Classification | GPCR |
The target: GPR153, gene name: GPR153, also named as PGR1. This gene encodes an integral membrane protein that belongs to the Class A rhodopsin superfamily of G protein coupled receptors. The encoded protein is expressed primarily in the central nervous system. A knockdown of the orthologous gene in rat is associated with a significant reduction in food intake and impaired decision making ability. Mutations in this gene are associated with schizophrenia, autism, and other neuropsychiatric disorders. The expression of this gene is activated by the glioma-associated oncogene homolog 1 transcription factor which, in turn, is activated by sonic hedgehog in normal and tumorigenic cells. [provided by RefSeq, Feb 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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