Anti-GP176/ GPR176/ HB-954 monoclonal antibody

Anti-GP176/ GPR176/ HB-954 antibody for FACS & in-vivo assay

Target products collectionGo to GPR176/GPR176 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0524-Ab-1/ GM-Tg-hg-MP0524-Ab-2Anti-Human GPR176 monoclonal antibodyHuman
GM-Tg-rg-MP0524-Ab-1/ GM-Tg-rg-MP0524-Ab-2Anti-Rat GPR176 monoclonal antibodyRat
GM-Tg-mg-MP0524-Ab-1/ GM-Tg-mg-MP0524-Ab-2Anti-Mouse GPR176 monoclonal antibodyMouse
GM-Tg-cynog-MP0524-Ab-1/ GM-Tg-cynog-MP0524-Ab-2Anti-Cynomolgus/ Rhesus macaque GPR176 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0524-Ab-1/ GM-Tg-felg-MP0524-Ab-2Anti-Feline GPR176 monoclonal antibodyFeline
GM-Tg-cang-MP0524-Ab-1/ GM-Tg-cang-MP0524-Ab-2Anti-Canine GPR176 monoclonal antibodyCanine
GM-Tg-bovg-MP0524-Ab-1/ GM-Tg-bovg-MP0524-Ab-2Anti-Bovine GPR176 monoclonal antibodyBovine
GM-Tg-equg-MP0524-Ab-1/ GM-Tg-equg-MP0524-Ab-2Anti-Equine GPR176 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0524-Ab-1/ GM-Tg-hg-MP0524-Ab-2; GM-Tg-rg-MP0524-Ab-1/ GM-Tg-rg-MP0524-Ab-2;
GM-Tg-mg-MP0524-Ab-1/ GM-Tg-mg-MP0524-Ab-2; GM-Tg-cynog-MP0524-Ab-1/ GM-Tg-cynog-MP0524-Ab-2;
GM-Tg-felg-MP0524-Ab-1/ GM-Tg-felg-MP0524-Ab-2; GM-Tg-cang-MP0524-Ab-1/ GM-Tg-cang-MP0524-Ab-2;
GM-Tg-bovg-MP0524-Ab-1/ GM-Tg-bovg-MP0524-Ab-2; GM-Tg-equg-MP0524-Ab-1/ GM-Tg-equg-MP0524-Ab-2
Products NameAnti-GPR176 monoclonal antibody
Formatmab
Target NameGPR176
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-GPR176 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species GP176/ GPR176/ HB-954 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0524
    Target NameGPR176
    Gene ID11245,381413,117257,701115,487488,101092188,525734,100057438
    Gene Symbol and SynonymsGm1012,Gpr,GPR176,HB-954,RBU-15
    Uniprot AccessionQ14439,Q64017
    Uniprot Entry NameGP176_HUMAN,GP176_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000166073
    Target ClassificationGPCR

    The target: GPR176, gene name: GPR176, also named as HB-954. Members of the G protein-coupled receptor family, such as GPR176, are cell surface receptors involved in responses to hormones, growth factors, and neurotransmitters (Hata et al., 1995 [PubMed 7893747]).[supplied by OMIM, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.