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Anti-MTR1L/ GPR50/ H9 monoclonal antibody
Anti-MTR1L/ GPR50/ H9 antibody for FACS & in-vivo assay
Go to GPR50/GPR50 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0537-Ab-1/ GM-Tg-hg-MP0537-Ab-2 | Anti-Human GPR50 monoclonal antibody | Human |
| GM-Tg-rg-MP0537-Ab-1/ GM-Tg-rg-MP0537-Ab-2 | Anti-Rat GPR50 monoclonal antibody | Rat |
| GM-Tg-mg-MP0537-Ab-1/ GM-Tg-mg-MP0537-Ab-2 | Anti-Mouse GPR50 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0537-Ab-1/ GM-Tg-cynog-MP0537-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GPR50 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0537-Ab-1/ GM-Tg-felg-MP0537-Ab-2 | Anti-Feline GPR50 monoclonal antibody | Feline |
| GM-Tg-cang-MP0537-Ab-1/ GM-Tg-cang-MP0537-Ab-2 | Anti-Canine GPR50 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0537-Ab-1/ GM-Tg-bovg-MP0537-Ab-2 | Anti-Bovine GPR50 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0537-Ab-1/ GM-Tg-equg-MP0537-Ab-2 | Anti-Equine GPR50 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0537-Ab-1/ GM-Tg-hg-MP0537-Ab-2; GM-Tg-rg-MP0537-Ab-1/ GM-Tg-rg-MP0537-Ab-2; GM-Tg-mg-MP0537-Ab-1/ GM-Tg-mg-MP0537-Ab-2; GM-Tg-cynog-MP0537-Ab-1/ GM-Tg-cynog-MP0537-Ab-2; GM-Tg-felg-MP0537-Ab-1/ GM-Tg-felg-MP0537-Ab-2; GM-Tg-cang-MP0537-Ab-1/ GM-Tg-cang-MP0537-Ab-2; GM-Tg-bovg-MP0537-Ab-1/ GM-Tg-bovg-MP0537-Ab-2; GM-Tg-equg-MP0537-Ab-1/ GM-Tg-equg-MP0537-Ab-2 |
| Products Name | Anti-GPR50 monoclonal antibody |
| Format | mab |
| Target Name | GPR50 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GPR50 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species MTR1L/ GPR50/ H9 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP003115 | human GPR50 Lentivirus plasmid |
| ORF Viral Vector | vGMLP003115 | human GPR50 Lentivirus particle |
| ORF Viral Vector | pGMLPm003199 | mouse Gpr50 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003199 | mouse Gpr50 Lentivirus particle |
Target information
| Target ID | GM-MP0537 |
| Target Name | GPR50 |
| Gene ID | 9248,14765,117097,703817,492213,101094577,530065,100069508 |
| Gene Symbol and Synonyms | GPR50,H9,Mel1c |
| Uniprot Accession | Q13585,Q62953 |
| Uniprot Entry Name | MTR1L_HUMAN,MTR1L_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000102195 |
| Target Classification | GPCR |
The target: GPR50, gene name: GPR50, also named as H9, Mel1c. This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women. [provided by RefSeq, Jan 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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