Anti-GPC5B/ GPRC5B/ RAIG-2 monoclonal antibody

Anti-GPC5B/ GPRC5B/ RAIG-2 antibody for FACS & in-vivo assay

Target products collectionGo to GPRC5B/GPRC5B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0552-Ab-1/ GM-Tg-hg-MP0552-Ab-2Anti-Human GPRC5B monoclonal antibodyHuman
GM-Tg-rg-MP0552-Ab-1/ GM-Tg-rg-MP0552-Ab-2Anti-Rat GPRC5B monoclonal antibodyRat
GM-Tg-mg-MP0552-Ab-1/ GM-Tg-mg-MP0552-Ab-2Anti-Mouse GPRC5B monoclonal antibodyMouse
GM-Tg-cynog-MP0552-Ab-1/ GM-Tg-cynog-MP0552-Ab-2Anti-Cynomolgus/ Rhesus macaque GPRC5B monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0552-Ab-1/ GM-Tg-felg-MP0552-Ab-2Anti-Feline GPRC5B monoclonal antibodyFeline
GM-Tg-cang-MP0552-Ab-1/ GM-Tg-cang-MP0552-Ab-2Anti-Canine GPRC5B monoclonal antibodyCanine
GM-Tg-bovg-MP0552-Ab-1/ GM-Tg-bovg-MP0552-Ab-2Anti-Bovine GPRC5B monoclonal antibodyBovine
GM-Tg-equg-MP0552-Ab-1/ GM-Tg-equg-MP0552-Ab-2Anti-Equine GPRC5B monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0552-Ab-1/ GM-Tg-hg-MP0552-Ab-2; GM-Tg-rg-MP0552-Ab-1/ GM-Tg-rg-MP0552-Ab-2;
GM-Tg-mg-MP0552-Ab-1/ GM-Tg-mg-MP0552-Ab-2; GM-Tg-cynog-MP0552-Ab-1/ GM-Tg-cynog-MP0552-Ab-2;
GM-Tg-felg-MP0552-Ab-1/ GM-Tg-felg-MP0552-Ab-2; GM-Tg-cang-MP0552-Ab-1/ GM-Tg-cang-MP0552-Ab-2;
GM-Tg-bovg-MP0552-Ab-1/ GM-Tg-bovg-MP0552-Ab-2; GM-Tg-equg-MP0552-Ab-1/ GM-Tg-equg-MP0552-Ab-2
Products NameAnti-GPRC5B monoclonal antibody
Formatmab
Target NameGPRC5B
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-GPRC5B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species GPC5B/ GPRC5B/ RAIG-2 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0552
    Target NameGPRC5B
    Gene ID51704,64297,293546,695204,100856475,101093231,516334,100052112
    Gene Symbol and SynonymsGPRC5B,RAIG-2,RAIG2
    Uniprot AccessionQ9NZH0
    Uniprot Entry NameGPC5B_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000167191
    Target ClassificationGPCR

    The target: GPRC5B, gene name: GPRC5B, also named as RAIG-2, RAIG2. This gene encodes a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The encoded protein may modulate insulin secretion and increased protein expression is associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.