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Anti-GPSM2/ CMCS/ DFNB82 monoclonal antibody
Anti-GPSM2/ CMCS/ DFNB82 antibody for FACS & in-vivo assay
Go to GPSM2/GPSM2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0554-Ab-1/ GM-Tg-hg-MP0554-Ab-2 | Anti-Human GPSM2 monoclonal antibody | Human |
| GM-Tg-rg-MP0554-Ab-1/ GM-Tg-rg-MP0554-Ab-2 | Anti-Rat GPSM2 monoclonal antibody | Rat |
| GM-Tg-mg-MP0554-Ab-1/ GM-Tg-mg-MP0554-Ab-2 | Anti-Mouse GPSM2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0554-Ab-1/ GM-Tg-cynog-MP0554-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GPSM2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0554-Ab-1/ GM-Tg-felg-MP0554-Ab-2 | Anti-Feline GPSM2 monoclonal antibody | Feline |
| GM-Tg-cang-MP0554-Ab-1/ GM-Tg-cang-MP0554-Ab-2 | Anti-Canine GPSM2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0554-Ab-1/ GM-Tg-bovg-MP0554-Ab-2 | Anti-Bovine GPSM2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0554-Ab-1/ GM-Tg-equg-MP0554-Ab-2 | Anti-Equine GPSM2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0554-Ab-1/ GM-Tg-hg-MP0554-Ab-2; GM-Tg-rg-MP0554-Ab-1/ GM-Tg-rg-MP0554-Ab-2; GM-Tg-mg-MP0554-Ab-1/ GM-Tg-mg-MP0554-Ab-2; GM-Tg-cynog-MP0554-Ab-1/ GM-Tg-cynog-MP0554-Ab-2; GM-Tg-felg-MP0554-Ab-1/ GM-Tg-felg-MP0554-Ab-2; GM-Tg-cang-MP0554-Ab-1/ GM-Tg-cang-MP0554-Ab-2; GM-Tg-bovg-MP0554-Ab-1/ GM-Tg-bovg-MP0554-Ab-2; GM-Tg-equg-MP0554-Ab-1/ GM-Tg-equg-MP0554-Ab-2 |
| Products Name | Anti-GPSM2 monoclonal antibody |
| Format | mab |
| Target Name | GPSM2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GPSM2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species GPSM2/ CMCS/ DFNB82 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm004113 | mouse Gpsm2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004113 | mouse Gpsm2 Lentivirus particle |
Target information
| Target ID | GM-MP0554 |
| Target Name | GPSM2 |
| Gene ID | 29899,76123,362021,696458,490127,101088422,513654,100057975 |
| Gene Symbol and Synonyms | 6230410J09Rik,CMCS,DFNB82,GPSM2,LGN,PINS,RGD1560967 |
| Uniprot Accession | P81274 |
| Uniprot Entry Name | GPSM2_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000121957 |
| Target Classification | N/A |
The target: GPSM2, gene name: GPSM2, also named as CMCS, DFNB82, LGN, PINS. The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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