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Anti-GRID2/ GluD2/ SCAR18 monoclonal antibody
Anti-GRID2/ GluD2/ SCAR18 antibody for FACS & in-vivo assay
Go to GRID2/GRID2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0559-Ab-1/ GM-Tg-hg-MP0559-Ab-2 | Anti-Human GRID2 monoclonal antibody | Human |
| GM-Tg-rg-MP0559-Ab-1/ GM-Tg-rg-MP0559-Ab-2 | Anti-Rat GRID2 monoclonal antibody | Rat |
| GM-Tg-mg-MP0559-Ab-1/ GM-Tg-mg-MP0559-Ab-2 | Anti-Mouse GRID2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0559-Ab-1/ GM-Tg-cynog-MP0559-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GRID2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0559-Ab-1/ GM-Tg-felg-MP0559-Ab-2 | Anti-Feline GRID2 monoclonal antibody | Feline |
| GM-Tg-cang-MP0559-Ab-1/ GM-Tg-cang-MP0559-Ab-2 | Anti-Canine GRID2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0559-Ab-1/ GM-Tg-bovg-MP0559-Ab-2 | Anti-Bovine GRID2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0559-Ab-1/ GM-Tg-equg-MP0559-Ab-2 | Anti-Equine GRID2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0559-Ab-1/ GM-Tg-hg-MP0559-Ab-2; GM-Tg-rg-MP0559-Ab-1/ GM-Tg-rg-MP0559-Ab-2; GM-Tg-mg-MP0559-Ab-1/ GM-Tg-mg-MP0559-Ab-2; GM-Tg-cynog-MP0559-Ab-1/ GM-Tg-cynog-MP0559-Ab-2; GM-Tg-felg-MP0559-Ab-1/ GM-Tg-felg-MP0559-Ab-2; GM-Tg-cang-MP0559-Ab-1/ GM-Tg-cang-MP0559-Ab-2; GM-Tg-bovg-MP0559-Ab-1/ GM-Tg-bovg-MP0559-Ab-2; GM-Tg-equg-MP0559-Ab-1/ GM-Tg-equg-MP0559-Ab-2 |
| Products Name | Anti-GRID2 monoclonal antibody |
| Format | mab |
| Target Name | GRID2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GRID2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species GRID2/ GluD2/ SCAR18 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm003648 | mouse Grid2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003648 | mouse Grid2 Lentivirus particle |
Target information
| Target ID | GM-MP0559 |
| Target Name | GRID2 |
| Gene ID | 2895,14804,79220,704787,487863,101084622,536367,100053364 |
| Gene Symbol and Synonyms | B230104L07Rik,cpr,GluD2,GluRdelta2,GRID2,ho,Lc,Lc |
| Uniprot Accession | O43424,Q63226 |
| Uniprot Entry Name | GRID2_HUMAN,GRID2_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000152208 |
| Target Classification | N/A |
The target: GRID2, gene name: GRID2, also named as GluD2, SCAR18. The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans. [provided by RefSeq, Apr 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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