Anti-NMD3B/ GRIN3B/ GluN3B monoclonal antibody

Anti-NMD3B/ GRIN3B/ GluN3B antibody for FACS & in-vivo assay

Target products collectionGo to GRIN3B/GRIN3B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0561-Ab-1/ GM-Tg-hg-MP0561-Ab-2Anti-Human GRIN3B monoclonal antibodyHuman
GM-Tg-rg-MP0561-Ab-1/ GM-Tg-rg-MP0561-Ab-2Anti-Rat GRIN3B monoclonal antibodyRat
GM-Tg-mg-MP0561-Ab-1/ GM-Tg-mg-MP0561-Ab-2Anti-Mouse GRIN3B monoclonal antibodyMouse
GM-Tg-cynog-MP0561-Ab-1/ GM-Tg-cynog-MP0561-Ab-2Anti-Cynomolgus/ Rhesus macaque GRIN3B monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0561-Ab-1/ GM-Tg-felg-MP0561-Ab-2Anti-Feline GRIN3B monoclonal antibodyFeline
GM-Tg-cang-MP0561-Ab-1/ GM-Tg-cang-MP0561-Ab-2Anti-Canine GRIN3B monoclonal antibodyCanine
GM-Tg-bovg-MP0561-Ab-1/ GM-Tg-bovg-MP0561-Ab-2Anti-Bovine GRIN3B monoclonal antibodyBovine
GM-Tg-equg-MP0561-Ab-1/ GM-Tg-equg-MP0561-Ab-2Anti-Equine GRIN3B monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0561-Ab-1/ GM-Tg-hg-MP0561-Ab-2; GM-Tg-rg-MP0561-Ab-1/ GM-Tg-rg-MP0561-Ab-2;
GM-Tg-mg-MP0561-Ab-1/ GM-Tg-mg-MP0561-Ab-2; GM-Tg-cynog-MP0561-Ab-1/ GM-Tg-cynog-MP0561-Ab-2;
GM-Tg-felg-MP0561-Ab-1/ GM-Tg-felg-MP0561-Ab-2; GM-Tg-cang-MP0561-Ab-1/ GM-Tg-cang-MP0561-Ab-2;
GM-Tg-bovg-MP0561-Ab-1/ GM-Tg-bovg-MP0561-Ab-2; GM-Tg-equg-MP0561-Ab-1/ GM-Tg-equg-MP0561-Ab-2
Products NameAnti-GRIN3B monoclonal antibody
Formatmab
Target NameGRIN3B
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-GRIN3B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species NMD3B/ GRIN3B/ GluN3B VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0561
    Target NameGRIN3B
    Gene ID116444,170483,170796,721155,485092,101094736,616000,111774159
    Gene Symbol and SynonymsGluN3B,GRIN3B,NMDAR3B,NR3B
    Uniprot AccessionO60391,Q8VHN2
    Uniprot Entry NameNMD3B_HUMAN,NMD3B_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000116032
    Target ClassificationN/A

    The target: GRIN3B, gene name: GRIN3B, also named as GluN3B, NR3B. The protein encoded by this gene is a subunit of an N-methyl-D-aspartate (NMDA) receptor. The encoded protein is found primarily in motor neurons, where it forms a heterotetramer with GRIN1 to create an excitatory glycine receptor. Variations in this gene have been proposed to be linked to schizophrenia. [provided by RefSeq, Nov 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.