Anti-HEPH/ CPL monoclonal antibody

Anti-HEPH/ CPL antibody for FACS & in-vivo assay

Target products collectionGo to HEPH/HEPH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0575-Ab-1/ GM-Tg-hg-MP0575-Ab-2Anti-Human HEPH monoclonal antibodyHuman
GM-Tg-rg-MP0575-Ab-1/ GM-Tg-rg-MP0575-Ab-2Anti-Rat HEPH monoclonal antibodyRat
GM-Tg-mg-MP0575-Ab-1/ GM-Tg-mg-MP0575-Ab-2Anti-Mouse HEPH monoclonal antibodyMouse
GM-Tg-cynog-MP0575-Ab-1/ GM-Tg-cynog-MP0575-Ab-2Anti-Cynomolgus/ Rhesus macaque HEPH monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0575-Ab-1/ GM-Tg-felg-MP0575-Ab-2Anti-Feline HEPH monoclonal antibodyFeline
GM-Tg-cang-MP0575-Ab-1/ GM-Tg-cang-MP0575-Ab-2Anti-Canine HEPH monoclonal antibodyCanine
GM-Tg-bovg-MP0575-Ab-1/ GM-Tg-bovg-MP0575-Ab-2Anti-Bovine HEPH monoclonal antibodyBovine
GM-Tg-equg-MP0575-Ab-1/ GM-Tg-equg-MP0575-Ab-2Anti-Equine HEPH monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0575-Ab-1/ GM-Tg-hg-MP0575-Ab-2; GM-Tg-rg-MP0575-Ab-1/ GM-Tg-rg-MP0575-Ab-2;
GM-Tg-mg-MP0575-Ab-1/ GM-Tg-mg-MP0575-Ab-2; GM-Tg-cynog-MP0575-Ab-1/ GM-Tg-cynog-MP0575-Ab-2;
GM-Tg-felg-MP0575-Ab-1/ GM-Tg-felg-MP0575-Ab-2; GM-Tg-cang-MP0575-Ab-1/ GM-Tg-cang-MP0575-Ab-2;
GM-Tg-bovg-MP0575-Ab-1/ GM-Tg-bovg-MP0575-Ab-2; GM-Tg-equg-MP0575-Ab-1/ GM-Tg-equg-MP0575-Ab-2
Products NameAnti-HEPH monoclonal antibody
Formatmab
Target NameHEPH
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-HEPH benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species HEPH/ CPL VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0575
    Target NameHEPH
    Gene ID9843,15203,117240,709879,491926,101081526,510736,100065379
    Gene Symbol and SynonymsC130006F04Rik,CPL,HEPH,mKIAA0698,sla
    Uniprot AccessionQ9BQS7,Q920H8
    Uniprot Entry NameHEPH_HUMAN,HEPH_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000089472
    Target ClassificationN/A

    The target: HEPH, gene name: HEPH, also named as CPL. This gene encodes a member of the multicopper oxidase protein family. The encoded protein is involved in the transport of dietary iron from epithelial cells of the intestinal lumen into the circulatory system, and may be involved in copper transport and homeostasis. In mouse, defects in this gene can lead to severe microcytic anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.