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Anti-RGMC/ HJV/ HFE2 monoclonal antibody
Anti-RGMC/ HJV/ HFE2 antibody for FACS & in-vivo assay
Go to HJV/HJV products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0578-Ab-1/ GM-Tg-hg-MP0578-Ab-2 | Anti-Human HJV monoclonal antibody | Human |
| GM-Tg-rg-MP0578-Ab-1/ GM-Tg-rg-MP0578-Ab-2 | Anti-Rat HJV monoclonal antibody | Rat |
| GM-Tg-mg-MP0578-Ab-1/ GM-Tg-mg-MP0578-Ab-2 | Anti-Mouse HJV monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0578-Ab-1/ GM-Tg-cynog-MP0578-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HJV monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0578-Ab-1/ GM-Tg-felg-MP0578-Ab-2 | Anti-Feline HJV monoclonal antibody | Feline |
| GM-Tg-cang-MP0578-Ab-1/ GM-Tg-cang-MP0578-Ab-2 | Anti-Canine HJV monoclonal antibody | Canine |
| GM-Tg-bovg-MP0578-Ab-1/ GM-Tg-bovg-MP0578-Ab-2 | Anti-Bovine HJV monoclonal antibody | Bovine |
| GM-Tg-equg-MP0578-Ab-1/ GM-Tg-equg-MP0578-Ab-2 | Anti-Equine HJV monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0578-Ab-1/ GM-Tg-hg-MP0578-Ab-2; GM-Tg-rg-MP0578-Ab-1/ GM-Tg-rg-MP0578-Ab-2; GM-Tg-mg-MP0578-Ab-1/ GM-Tg-mg-MP0578-Ab-2; GM-Tg-cynog-MP0578-Ab-1/ GM-Tg-cynog-MP0578-Ab-2; GM-Tg-felg-MP0578-Ab-1/ GM-Tg-felg-MP0578-Ab-2; GM-Tg-cang-MP0578-Ab-1/ GM-Tg-cang-MP0578-Ab-2; GM-Tg-bovg-MP0578-Ab-1/ GM-Tg-bovg-MP0578-Ab-2; GM-Tg-equg-MP0578-Ab-1/ GM-Tg-equg-MP0578-Ab-2 |
| Products Name | Anti-HJV monoclonal antibody |
| Format | mab |
| Target Name | HJV |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HJV benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species RGMC/ HJV/ HFE2 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP0578 |
| Target Name | HJV |
| Gene ID | 148738,69585,310681,698805,475830,101099991,100335368,111773537 |
| Gene Symbol and Synonyms | 2310035L15Rik,5230400G09Rik,DL-M,hemojuvelin,HFE2,HFE2A,HJV,JH,RGMC |
| Uniprot Accession | Q6ZVN8,Q8N7M5 |
| Uniprot Entry Name | RGMC_HUMAN,RGMC_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Lung Cancer, Acute kidney failure |
| Gene Ensembl | ENSG00000168509 |
| Target Classification | N/A |
The target: HJV, gene name: HJV, also named as HFE2, HFE2A, JH, RGMC. The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. [provided by RefSeq, Oct 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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