Anti-HGNAT/ HGSNAT/ MPS3C monoclonal antibody

Anti-HGNAT/ HGSNAT/ MPS3C antibody for FACS & in-vivo assay

Target products collectionGo to HGSNAT/HGSNAT products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0579-Ab-1/ GM-Tg-hg-MP0579-Ab-2Anti-Human HGSNAT monoclonal antibodyHuman
GM-Tg-rg-MP0579-Ab-1/ GM-Tg-rg-MP0579-Ab-2Anti-Rat HGSNAT monoclonal antibodyRat
GM-Tg-mg-MP0579-Ab-1/ GM-Tg-mg-MP0579-Ab-2Anti-Mouse HGSNAT monoclonal antibodyMouse
GM-Tg-cynog-MP0579-Ab-1/ GM-Tg-cynog-MP0579-Ab-2Anti-Cynomolgus/ Rhesus macaque HGSNAT monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0579-Ab-1/ GM-Tg-felg-MP0579-Ab-2Anti-Feline HGSNAT monoclonal antibodyFeline
GM-Tg-cang-MP0579-Ab-1/ GM-Tg-cang-MP0579-Ab-2Anti-Canine HGSNAT monoclonal antibodyCanine
GM-Tg-bovg-MP0579-Ab-1/ GM-Tg-bovg-MP0579-Ab-2Anti-Bovine HGSNAT monoclonal antibodyBovine
GM-Tg-equg-MP0579-Ab-1/ GM-Tg-equg-MP0579-Ab-2Anti-Equine HGSNAT monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0579-Ab-1/ GM-Tg-hg-MP0579-Ab-2; GM-Tg-rg-MP0579-Ab-1/ GM-Tg-rg-MP0579-Ab-2;
GM-Tg-mg-MP0579-Ab-1/ GM-Tg-mg-MP0579-Ab-2; GM-Tg-cynog-MP0579-Ab-1/ GM-Tg-cynog-MP0579-Ab-2;
GM-Tg-felg-MP0579-Ab-1/ GM-Tg-felg-MP0579-Ab-2; GM-Tg-cang-MP0579-Ab-1/ GM-Tg-cang-MP0579-Ab-2;
GM-Tg-bovg-MP0579-Ab-1/ GM-Tg-bovg-MP0579-Ab-2; GM-Tg-equg-MP0579-Ab-1/ GM-Tg-equg-MP0579-Ab-2
Products NameAnti-HGSNAT monoclonal antibody
Formatmab
Target NameHGSNAT
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-HGSNAT benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species HGNAT/ HGSNAT/ MPS3C VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0579
    Target NameHGSNAT
    Gene ID138050,52120,361165,720331,482833,101101049,511607,100053359
    Gene Symbol and Synonyms9430010M12Rik,D8Ertd354e,HGNAT,HGSNAT,MPS3C,RGD1560755,RP73,™EM76
    Uniprot AccessionQ68CP4
    Uniprot Entry NameHGNAT_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000165102
    Target ClassificationN/A

    The target: HGSNAT, gene name: HGSNAT, also named as HGNAT, MPS3C, RP73, ™EM76. This gene encodes a lysosomal acetyltransferase, which is one of several enzymes involved in the lysosomal degradation of heparin sulfate. Mutations in this gene are associated with Sanfilippo syndrome C, one type of the lysosomal storage disease mucopolysaccaridosis III, which results from impaired degradation of heparan sulfate. [provided by RefSeq, Jan 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.