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Anti-DPA1/ HLA-DPA1/ DP(W3) monoclonal antibody
Anti-DPA1/ HLA-DPA1/ DP(W3) antibody for FACS & in-vivo assay
Go to HLA-DPA1/HLA-DPA1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0583-Ab-1/ GM-Tg-hg-MP0583-Ab-2 | Anti-Human HLA-DPA1 monoclonal antibody | Human |
| GM-Tg-rg-MP0583-Ab-1/ GM-Tg-rg-MP0583-Ab-2 | Anti-Rat HLA-DPA1 monoclonal antibody | Rat |
| GM-Tg-mg-MP0583-Ab-1/ GM-Tg-mg-MP0583-Ab-2 | Anti-Mouse HLA-DPA1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0583-Ab-1/ GM-Tg-cynog-MP0583-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HLA-DPA1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0583-Ab-1/ GM-Tg-felg-MP0583-Ab-2 | Anti-Feline HLA-DPA1 monoclonal antibody | Feline |
| GM-Tg-cang-MP0583-Ab-1/ GM-Tg-cang-MP0583-Ab-2 | Anti-Canine HLA-DPA1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0583-Ab-1/ GM-Tg-bovg-MP0583-Ab-2 | Anti-Bovine HLA-DPA1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0583-Ab-1/ GM-Tg-equg-MP0583-Ab-2 | Anti-Equine HLA-DPA1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0583-Ab-1/ GM-Tg-hg-MP0583-Ab-2; GM-Tg-rg-MP0583-Ab-1/ GM-Tg-rg-MP0583-Ab-2; GM-Tg-mg-MP0583-Ab-1/ GM-Tg-mg-MP0583-Ab-2; GM-Tg-cynog-MP0583-Ab-1/ GM-Tg-cynog-MP0583-Ab-2; GM-Tg-felg-MP0583-Ab-1/ GM-Tg-felg-MP0583-Ab-2; GM-Tg-cang-MP0583-Ab-1/ GM-Tg-cang-MP0583-Ab-2; GM-Tg-bovg-MP0583-Ab-1/ GM-Tg-bovg-MP0583-Ab-2; GM-Tg-equg-MP0583-Ab-1/ GM-Tg-equg-MP0583-Ab-2 |
| Products Name | Anti-HLA-DPA1 monoclonal antibody |
| Format | mab |
| Target Name | HLA-DPA1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HLA-DPA1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species DPA1/ HLA-DPA1/ DP(W3) VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP004033 | human HLA-DPA1 Lentivirus particle |
| ORF Viral Vector | pGMLP002639 | human HLA-DPA1 Lentivirus plasmid |
| ORF Viral Vector | pGMLP004033 | human HLA-DPA1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002639 | human HLA-DPA1 Lentivirus particle |
Target information
| Target ID | GM-MP0583 |
| Target Name | HLA-DPA1 |
| Gene ID | 3113,24986,717992 |
| Gene Symbol and Synonyms | DP(W3),DP(W4),DPA1,HLA-DP1A,HLA-DPA,HLA-DPA1,HLA-DPB1,HLADP,HLASB,MAMU-DPA,Mamu-DPA1,PLT1,RT1-Ha,RT1.Ha |
| Uniprot Accession | P20036 |
| Uniprot Entry Name | DPA1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000231389 |
| Target Classification | N/A |
The target: HLA-DPA1, gene name: HLA-DPA1, also named as DP(W3), DP(W4), HLA-DP1A, HLADP, HLASB, PLT1. HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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