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Anti-DPB1/ HLA-DPB1/ HLA-DP monoclonal antibody
Anti-DPB1/ HLA-DPB1/ HLA-DP antibody for FACS & in-vivo assay
Go to HLA-DPB1/HLA-DPB1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0584-Ab-1/ GM-Tg-hg-MP0584-Ab-2 | Anti-Human HLA-DPB1 monoclonal antibody | Human |
| GM-Tg-rg-MP0584-Ab-1/ GM-Tg-rg-MP0584-Ab-2 | Anti-Rat HLA-DPB1 monoclonal antibody | Rat |
| GM-Tg-mg-MP0584-Ab-1/ GM-Tg-mg-MP0584-Ab-2 | Anti-Mouse HLA-DPB1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0584-Ab-1/ GM-Tg-cynog-MP0584-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HLA-DPB1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0584-Ab-1/ GM-Tg-felg-MP0584-Ab-2 | Anti-Feline HLA-DPB1 monoclonal antibody | Feline |
| GM-Tg-cang-MP0584-Ab-1/ GM-Tg-cang-MP0584-Ab-2 | Anti-Canine HLA-DPB1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0584-Ab-1/ GM-Tg-bovg-MP0584-Ab-2 | Anti-Bovine HLA-DPB1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0584-Ab-1/ GM-Tg-equg-MP0584-Ab-2 | Anti-Equine HLA-DPB1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0584-Ab-1/ GM-Tg-hg-MP0584-Ab-2; GM-Tg-rg-MP0584-Ab-1/ GM-Tg-rg-MP0584-Ab-2; GM-Tg-mg-MP0584-Ab-1/ GM-Tg-mg-MP0584-Ab-2; GM-Tg-cynog-MP0584-Ab-1/ GM-Tg-cynog-MP0584-Ab-2; GM-Tg-felg-MP0584-Ab-1/ GM-Tg-felg-MP0584-Ab-2; GM-Tg-cang-MP0584-Ab-1/ GM-Tg-cang-MP0584-Ab-2; GM-Tg-bovg-MP0584-Ab-1/ GM-Tg-bovg-MP0584-Ab-2; GM-Tg-equg-MP0584-Ab-1/ GM-Tg-equg-MP0584-Ab-2 |
| Products Name | Anti-HLA-DPB1 monoclonal antibody |
| Format | mab |
| Target Name | HLA-DPB1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HLA-DPB1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species DPB1/ HLA-DPB1/ HLA-DP VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP004458 | human HLA-DPB1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP004458 | human HLA-DPB1 Lentivirus particle |
Target information
| Target ID | GM-MP0584 |
| Target Name | HLA-DPB1 |
| Gene ID | 3115,717969,111556176 |
| Gene Symbol and Synonyms | DPB1,HLA-DP,HLA-DP1B,HLA-DPB,HLA-DPB1,LOC111556176,MAMU-DPB,Mamu-DPB1 |
| Uniprot Accession | P04440 |
| Uniprot Entry Name | DPB1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000223865 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: HLA-DPB1, gene name: HLA-DPB1, also named as DPB1, HLA-DP, HLA-DP1B, HLA-DPB. HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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