Anti-DQB1/ HLA-DQB1/ CELIAC1 monoclonal antibody

Anti-DQB1/ HLA-DQB1/ CELIAC1 antibody for FACS & in-vivo assay

Target products collectionGo to HLA-DQB1/HLA-DQB1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0586-Ab-1/ GM-Tg-hg-MP0586-Ab-2Anti-Human HLA-DQB1 monoclonal antibodyHuman
GM-Tg-rg-MP0586-Ab-1/ GM-Tg-rg-MP0586-Ab-2Anti-Rat HLA-DQB1 monoclonal antibodyRat
GM-Tg-mg-MP0586-Ab-1/ GM-Tg-mg-MP0586-Ab-2Anti-Mouse HLA-DQB1 monoclonal antibodyMouse
GM-Tg-cynog-MP0586-Ab-1/ GM-Tg-cynog-MP0586-Ab-2Anti-Cynomolgus/ Rhesus macaque HLA-DQB1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0586-Ab-1/ GM-Tg-felg-MP0586-Ab-2Anti-Feline HLA-DQB1 monoclonal antibodyFeline
GM-Tg-cang-MP0586-Ab-1/ GM-Tg-cang-MP0586-Ab-2Anti-Canine HLA-DQB1 monoclonal antibodyCanine
GM-Tg-bovg-MP0586-Ab-1/ GM-Tg-bovg-MP0586-Ab-2Anti-Bovine HLA-DQB1 monoclonal antibodyBovine
GM-Tg-equg-MP0586-Ab-1/ GM-Tg-equg-MP0586-Ab-2Anti-Equine HLA-DQB1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0586-Ab-1/ GM-Tg-hg-MP0586-Ab-2; GM-Tg-rg-MP0586-Ab-1/ GM-Tg-rg-MP0586-Ab-2;
GM-Tg-mg-MP0586-Ab-1/ GM-Tg-mg-MP0586-Ab-2; GM-Tg-cynog-MP0586-Ab-1/ GM-Tg-cynog-MP0586-Ab-2;
GM-Tg-felg-MP0586-Ab-1/ GM-Tg-felg-MP0586-Ab-2; GM-Tg-cang-MP0586-Ab-1/ GM-Tg-cang-MP0586-Ab-2;
GM-Tg-bovg-MP0586-Ab-1/ GM-Tg-bovg-MP0586-Ab-2; GM-Tg-equg-MP0586-Ab-1/ GM-Tg-equg-MP0586-Ab-2
Products NameAnti-HLA-DQB1 monoclonal antibody
Formatmab
Target NameHLA-DQB1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-HLA-DQB1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species DQB1/ HLA-DQB1/ CELIAC1 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP002641human HLA-DQB1 Lentivirus particle
    ORF Viral VectorpGMLV000874human HLA-DQB1 Lentivirus plasmid
    ORF Viral VectorpGMLP002641human HLA-DQB1 Lentivirus plasmid
    ORF Viral VectorvGMLV000874human HLA-DQB1 Lentivirus particle
    ORF Viral VectorpGMLPm003456mouse H2-Ab1 Lentivirus plasmid
    ORF Viral VectorvGMLPm003456mouse H2-Ab1 Lentivirus particle


    Target information

    Target IDGM-MP0586
    Target NameHLA-DQB1
    Gene ID3119
    Gene Symbol and SynonymsCELIAC1,DLA-DQB,DLA-DQB1,DLA-DQBC1,DQB,HLA-DQB,HLA-DQB1,IDDM1
    Uniprot AccessionP01920
    Uniprot Entry NameDQB1_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseCancer
    Gene EnsemblENSG00000179344
    Target ClassificationTumor-associated antigen (TAA)

    The target: HLA-DQB1, gene name: HLA-DQB1, also named as CELIAC1, HLA-DQB, IDDM1. HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.