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Anti-HLAE/ HLA-E/ HLA-6.2 monoclonal antibody
Anti-HLAE/ HLA-E/ HLA-6.2 antibody for FACS & in-vivo assay
Go to HLA-E/HLA-E products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0588-Ab-1/ GM-Tg-hg-MP0588-Ab-2 | Anti-Human HLA-E monoclonal antibody | Human |
| GM-Tg-rg-MP0588-Ab-1/ GM-Tg-rg-MP0588-Ab-2 | Anti-Rat HLA-E monoclonal antibody | Rat |
| GM-Tg-mg-MP0588-Ab-1/ GM-Tg-mg-MP0588-Ab-2 | Anti-Mouse HLA-E monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0588-Ab-1/ GM-Tg-cynog-MP0588-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HLA-E monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0588-Ab-1/ GM-Tg-felg-MP0588-Ab-2 | Anti-Feline HLA-E monoclonal antibody | Feline |
| GM-Tg-cang-MP0588-Ab-1/ GM-Tg-cang-MP0588-Ab-2 | Anti-Canine HLA-E monoclonal antibody | Canine |
| GM-Tg-bovg-MP0588-Ab-1/ GM-Tg-bovg-MP0588-Ab-2 | Anti-Bovine HLA-E monoclonal antibody | Bovine |
| GM-Tg-equg-MP0588-Ab-1/ GM-Tg-equg-MP0588-Ab-2 | Anti-Equine HLA-E monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0588-Ab-1/ GM-Tg-hg-MP0588-Ab-2; GM-Tg-rg-MP0588-Ab-1/ GM-Tg-rg-MP0588-Ab-2; GM-Tg-mg-MP0588-Ab-1/ GM-Tg-mg-MP0588-Ab-2; GM-Tg-cynog-MP0588-Ab-1/ GM-Tg-cynog-MP0588-Ab-2; GM-Tg-felg-MP0588-Ab-1/ GM-Tg-felg-MP0588-Ab-2; GM-Tg-cang-MP0588-Ab-1/ GM-Tg-cang-MP0588-Ab-2; GM-Tg-bovg-MP0588-Ab-1/ GM-Tg-bovg-MP0588-Ab-2; GM-Tg-equg-MP0588-Ab-1/ GM-Tg-equg-MP0588-Ab-2 |
| Products Name | Anti-HLA-E monoclonal antibody |
| Format | mab |
| Target Name | HLA-E |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HLA-E benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species HLAE/ HLA-E/ HLA-6.2 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP002654 | human HLA-E Lentivirus plasmid |
| ORF Viral Vector | vGMLP002654 | human HLA-E Lentivirus particle |
| ORF Viral Vector | pGMLPm003807 | mouse H2-T23 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003807 | mouse H2-T23 Lentivirus particle |
Target information
| Target ID | GM-MP0588 |
| Target Name | HLA-E |
| Gene ID | 3133,109500088 |
| Gene Symbol and Synonyms | HLA-6.2,HLA-E,LOC109500088,QA1 |
| Uniprot Accession | P13747 |
| Uniprot Entry Name | HLAE_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000204592 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: HLA-E, gene name: HLA-E, also named as HLA-6.2, QA1. HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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