Anti-5HT3E/ HTR3E/ 5-HT3-E monoclonal antibody

Anti-5HT3E/ HTR3E/ 5-HT3-E antibody for FACS & in-vivo assay

Target products collectionGo to HTR3E/HTR3E products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0594-Ab-1/ GM-Tg-hg-MP0594-Ab-2Anti-Human HTR3E monoclonal antibodyHuman
GM-Tg-rg-MP0594-Ab-1/ GM-Tg-rg-MP0594-Ab-2Anti-Rat HTR3E monoclonal antibodyRat
GM-Tg-mg-MP0594-Ab-1/ GM-Tg-mg-MP0594-Ab-2Anti-Mouse HTR3E monoclonal antibodyMouse
GM-Tg-cynog-MP0594-Ab-1/ GM-Tg-cynog-MP0594-Ab-2Anti-Cynomolgus/ Rhesus macaque HTR3E monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0594-Ab-1/ GM-Tg-felg-MP0594-Ab-2Anti-Feline HTR3E monoclonal antibodyFeline
GM-Tg-cang-MP0594-Ab-1/ GM-Tg-cang-MP0594-Ab-2Anti-Canine HTR3E monoclonal antibodyCanine
GM-Tg-bovg-MP0594-Ab-1/ GM-Tg-bovg-MP0594-Ab-2Anti-Bovine HTR3E monoclonal antibodyBovine
GM-Tg-equg-MP0594-Ab-1/ GM-Tg-equg-MP0594-Ab-2Anti-Equine HTR3E monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0594-Ab-1/ GM-Tg-hg-MP0594-Ab-2; GM-Tg-rg-MP0594-Ab-1/ GM-Tg-rg-MP0594-Ab-2;
GM-Tg-mg-MP0594-Ab-1/ GM-Tg-mg-MP0594-Ab-2; GM-Tg-cynog-MP0594-Ab-1/ GM-Tg-cynog-MP0594-Ab-2;
GM-Tg-felg-MP0594-Ab-1/ GM-Tg-felg-MP0594-Ab-2; GM-Tg-cang-MP0594-Ab-1/ GM-Tg-cang-MP0594-Ab-2;
GM-Tg-bovg-MP0594-Ab-1/ GM-Tg-bovg-MP0594-Ab-2; GM-Tg-equg-MP0594-Ab-1/ GM-Tg-equg-MP0594-Ab-2
Products NameAnti-HTR3E monoclonal antibody
Formatmab
Target NameHTR3E
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-HTR3E benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species 5HT3E/ HTR3E/ 5-HT3-E VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP0594
    Target NameHTR3E
    Gene ID285242,100424421,101089387
    Gene Symbol and Synonyms5-HT3-E,5-HT3c1,5-HT3E,HTR3E
    Uniprot AccessionA5X5Y0
    Uniprot Entry Name5HT3E_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000186038
    Target ClassificationN/A

    The target: HTR3E, gene name: HTR3E, also named as 5-HT3-E, 5-HT3E, 5-HT3c1. This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a role in neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome 3. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2012].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.